| Type | Description |
|---|---|
| Definition | glutamate-cysteine ligase modifier subunit |
| Date | Results | Publications |
|---|---|---|
| 2018-07-07 12:04:00 | Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 macrophages is tightly and differentially regulated via GCLC and GCLM subunits of glutamate cysteine ligase. | 28993271 |
| 2018-04-28 10:53:00 | Two promoter polymorphisms of GCLM (-588C/T) and GCLC (-128T/C) are associated with an increased risk of ischemic heart disease in Kazakhstan population. | 28757675 |
| 2018-01-27 10:43:00 | High GCLM expression is associated with chemotherapy resistance in breast cancer. | 26894974 |
| 2017-02-18 11:49:00 | Glutaminolysis is activated in ES2 and OVCAR3, though ES2 exclusively synthesizes amino acids and GSH. ES2 cells are more resistant to carboplatin than OVCAR3 and the abrogation of GSH production by BSO sensitizes ES2 to carboplatin. HNF1beta regulates the expression of GCLC, but not GCLM, and consequently GSH production in ES2 | 26520442 |
| 2016-10-29 11:59:00 | Data suggest gene expression in vascular endothelium is altered by dietary factors; aged garlic extract induces expression of HMOX1 (heme oxygenase-1) and GCLM via activation of NRF2-ARE (nuclear factor erythroid 2-antioxidant response element) signaling. | 26507778 |
| Type | IDs |
|---|---|
| Synonymous | GLCLR |
| Gene |
UniProtKB-ID:
GSH0_HUMAN
UniprotKB:
P48507
UniParc:
UPI000000D9B9,
UPI0002C37A36
EMBL:
CR541833,
AY773965,
AK290449,
BC041809,
AB809606,
AL117351,
AL049796,
L35546,
CH471097
Ensembl:
ENSG00000023909
KO:
hsa:2730
|
| Nucleutide sequences |
EMBL-CDS:
BAF83138.1,
BAN05309.1,
AAA65028.1,
EAW73060.1,
AAH41809.1,
EAW73061.1,
CAG46632.1,
AAV28733.1
Ensembl_TRS:
ENST00000615724,
ENST00000370238
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359258,
ENSP00000484507
RefSeq:
NP_001295182.1,
XP_016856545.1,
NP_002052.1,
XP_016856546.1,
XP_011539563.1
|
| Others |
UniRef100:
UniRef100_P48507
UniRef90:
UniRef90_P48507
UniRef50:
UniRef50_P48507
UniGene:
Hs.315562
CCDS:
CCDS746.1,
CCDS81352.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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