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9958 USP15

9958

USP15

ubiquitin specific peptidase 15

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquitin specific peptidase 15

研究结论

Date Results Publications
2021-03-20 13:24:00 TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis. 32101751
2020-06-20 12:25:00 modifications of USP15 and USP4 by phosphorylation are important for the regulation of their localization required for cellular function in the spliceosome. 31330151
2020-02-29 10:07:00 The molecular structure of USP15 and its ubiquitin variant inhibitors has been reported. 30713027
2019-11-23 12:33:00 USP15 participates in HCV propagation in hepatic cells. 30626683
2019-04-13 11:58:00 Study reports that USP15 affects cancer cell response to inhibitors by regulating homologous recombination repair. USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1. USP15 deubiquitinates BARD1 BRCT domain, and promotes BARD1-HP1gamma interaction, resulting in BRCA1/BARD1 retention at DSBs. Cancer-associated USP15 mutations, with decreased USP15-BARD1 interaction, increases Pduanyu37 inhibitor sensitivity. 30874560

名称对应

Type IDs
Synonymous UNPH-2, UNPH4
Gene
UniProtKB-ID: UBP15_HUMAN
UniprotKB: Q9Y4E8
UniParc: UPI000002B67D, UPI000002B67C, UPI00001379F8, UPI000006EC4F
EMBL: BC020688, AB011101, AF153604, AC079035, AC048342, AK023703, AF106069, AK292337, BC125123, BC063454, AC117370, AF013990
Ensembl: ENSG00000135655
KO: hsa:9958
Nucleutide sequences
EMBL-CDS: AAD52099.1, AAH20688.1, AAG28973.1, AAH63454.1, BAA25455.2, AAD41086.1, BAF85026.1, BAB14648.1, AAI25124.1
Ensembl_TRS: ENST00000280377, ENST00000353364, ENST00000312635
Protein sequencees
Ensembl_PRO: ENSP00000258123, ENSP00000309240, ENSP00000280377
RefSeq: NP_001338092.1, NP_001338090.1, NP_001239008.1, NP_001239007.1, NP_001338094.1, NP_001338088.1, NP_001338095.1, NP_001338089.1, NP_006304.1, NP_001338091.1, NP_001338093.1
Others
UniRef100: UniRef100_Q9Y4E8
UniRef90: UniRef90_Q9Y4E8
UniRef50: UniRef50_Q9Y4E8
UniGene: Hs.434951
CCDS: CCDS58250.1, CCDS58251.1, CCDS8963.1

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