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57409 MIF4GD

57409

MIF4GD

MIF4G domain containing

protein-coding

Homo sapiens

基因描述

Type Description
Definition MIF4G domain containing

研究结论

Date Results Publications
2015-05-02 11:35:00 Results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC. 24336329
2013-03-16 11:48:00 Data suggest that oligomerization and SLBP phosphorylation regulate SLBP-SLIP1-histone-mRNA complex formation/disassociation; sequential and ordered assembly is required. 23286197
2013-01-30 08:20:00 This paper describes the oligomeric state of SLIP1 and the SLIP1-SLBP complex and how it is regulated by SLBP phosphorylation. Using alanine scanning mutagenesis, the authors demonstrate that the binding site on SLIP1 for SLBP lies close to the dimer interface. A single-point mutant near the SLIP1 homodimer interface abolished interaction with SLBP in vitro and reduced the abundance of histone mRNA in vivo. 23286197
2012-07-28 11:33:00 INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs. 22532700
2010-01-21 00:00:00 downregulation of endogenous SLIP1 reduces the rate of translation of endogenous histone mRNA and also reduces cell viability. 18025107

名称对应

Type IDs
Synonymous AD023, MIFD, SLIP1
Gene
UniProtKB-ID: MI4GD_HUMAN, A0A0S2Z5S7_HUMAN, A0A0S2Z5K9_HUMAN, A0A3B3IU65_HUMAN, A0A0S2Z5T5_HUMAN
UniprotKB: A9UHW6, A0A0S2Z5S7, A0A0S2Z5K9, A0A3B3IU65, A0A0S2Z5T5
UniParc: UPI0004F00536, UPI0000200237, UPI0000072FB4, UPI0000D4CCCB
EMBL: AL555095, EU287989, AK300711, CH471099, KU178733, KU178732, AC022211, AF225422, KU178731, BC033759
Ensembl: ENSG00000125457
KO: hsa:57409
Nucleutide sequences
EMBL-CDS: BAG62389.1, AAH33759.1, AAG09724.1, ABX83907.1, EAW89263.1, ALQ34190.1, ALQ34191.1, ALQ34189.1
Ensembl_TRS: ENST00000577542, ENST00000618645, ENST00000325102, ENST00000579297, ENST00000245551, ENST00000649805
Protein sequencees
Ensembl_PRO: ENSP00000462459, ENSP00000463334, ENSP00000321625, ENSP00000245551, ENSP00000484245, ENSP00000498095
RefSeq: NP_001229430.1, XP_016880380.1, NP_001229427.1, NP_001352680.1, NP_001229429.1, XP_011523356.1, NP_001352682.1, NP_001352683.1, NP_001352681.1, XP_016880377.1, XP_016880379.1, NP_001357521.1, NP_001350735.1, XP_016880378.1, XP_011523354.1, XP_016880384.1, XP_011523357.1, NP_065730.2, NP_001352684.1
Others
UniRef100: UniRef100_A0A3B3IU65, UniRef100_A9UHW6, UniRef100_A0A2J8KBG9, UniRef100_A0A6D2XYI9
UniRef90: UniRef90_A0A3B3IU65, UniRef90_A0A2K5DHL6, UniRef90_A9UHW6, UniRef90_A0A2K6GQS9
UniRef50: UniRef50_A9UHW6, UniRef50_A0A2K5DHH2, UniRef50_G1QJ41
UniGene: Hs.325631
CCDS: CCDS56044.1, CCDS11719.1, CCDS58598.1

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研究热度

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