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4351 MPI

4351

MPI

mannose phosphate isomerase

protein-coding

Homo sapiens

基因描述

Type Description
Definition mannose phosphate isomerase

研究结论

Date Results Publications
2020-07-04 10:10:00 MPI loss is a driver of liver fibrosis and suggest that modulating mannose metabolism pathways could reduce hepatic stellate cell activation and improve hepatic fibrosis. 31016744
2018-03-10 11:15:00 This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53, and identifies mannose phosphate isomerase as a novel regulator of p53 and Warburg metabolism. 28644127
2011-12-31 10:39:00 Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts 21949237
2010-09-15 22:05:00 Meta-analysis of gene-disease association. (HuGE Navigator) 20628624
2010-01-21 00:00:00 The mannose-6-phosphate-enzyme complex is developed and the key residues involved in the ligand binding are determined. Our results suggest a hydride transfer mechanism of alpha-hydrogen between the C1 and C2 positions. 16488169

名称对应

Type IDs
Synonymous CDG1B, PMI, PMI1
Gene
UniProtKB-ID: MPI_HUMAN, H3BPP3_HUMAN, H3BPB8_HUMAN, B4DW50_HUMAN, F5GX71_HUMAN, Q8NHZ6_HUMAN
UniprotKB: P34949, H3BPP3, H3BPB8, B4DW50, F5GX71, Q8NHZ6
UniParc: UPI00017A81E6, UPI0000073EBD, UPI000006ED62, UPI000000DB74, UPI0000229CB0, UPI0002065542, UPI00001FE8D1
EMBL: BC017351, AF227216, AF227218, AC125435, BC046357, AK301370, AF504648, X76057, CH471136, AF227217, AK292374
Ensembl: ENSG00000178802
KO: hsa:4351
Nucleutide sequences
EMBL-CDS: AAH46357.1, AAF37697.1, CAA53657.1, EAW99296.1, AAH17351.1, BAF85063.1, EAW99295.1, BAG62912.1, AAM28199.1
Gene_ORFName: hCG_2006995
Ensembl_TRS: ENST00000323744, ENST00000352410, ENST00000566377, ENST00000563786, ENST00000535694
Protein sequencees
Ensembl_PRO: ENSP00000318318, ENSP00000318192, ENSP00000455405, ENSP00000455241, ENSP00000440447
RefSeq: NP_001276086.1, NP_001276085.1, NP_001317301.1, NP_002426.1, XP_016877697.1, XP_016877698.1, NP_001276084.1
Others
UniRef100: UniRef100_P34949, UniRef100_B4DW50, UniRef100_H3BPP3
UniRef90: UniRef90_H3BUZ9, UniRef90_P34949, UniRef90_B4DW50
UniRef50: UniRef50_P34949, UniRef50_A0A3Q2GXF5
UniGene: Hs.75694
CCDS: CCDS10272.1, CCDS73757.1

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