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5878 RAB5C

5878

RAB5C

RAB5C, member RAS oncogene family

protein-coding

Homo sapiens

基因描述

Type Description
Definition RAB5C, member RAS oncogene family

研究结论

Date Results Publications
2020-06-20 12:42:00 Rab5C orchestrates a mechanism of radioresistance in rectal adenocarcinoma cell. 30968159
2020-04-04 11:09:00 The results reveal that FAK activates Rab5, leading to cell migration. 31292193
2019-11-23 11:01:00 ASO rapidly trafficked to the late endosome/lysosome in poor productive uptake cells compared to those with more robust knockdown. An siRNA screen identified several factors mechanistically involved in productive ASO uptake, including the endosomal GTPase Rab5C 30927008
2019-07-06 12:02:00 Rab5C and EEA1 in the early endosomal pathway, and Rab7A and lysobisphosphatidic acid in the late endosomal pathway, are important for trafficking of phosphorothioate Antisense oligonucleotides and facilitate their escape from endolysosomal compartments after Stabilin-mediated internalization. 29437530
2018-10-11 12:42:00 We identify RAB5C as a new candidate gene for type-2 diabetes risk with a functional role in endosomal type-2 diabetes module. Functional analysis shows that RAB5C is tyrosine phosphorylated. Data analysis reveals a tyrosine phosphorylation motif in the GTP binding site of RAB5C which may be targeted by insulin receptor. Insulin-dependent tyrosine phosphorylation of RAB5C is inhibited by overexpression of HACD3 (PTPLAD1). 30300385

名称对应

Type IDs
Synonymous L1880, RAB5CL, RAB5L, RABL
Gene
UniProtKB-ID: RAB5C_HUMAN, A0A024R1U4_HUMAN
UniprotKB: P51148, A0A024R1U4
UniParc: UPI000000125E, UPI00018926DE
EMBL: BC106039, AK310234, U11293, U18420, AF498938, AC003104, CR541901, AF141304, BC114439, BT019484, AC099811, AC105024, CH471152
Ensembl: ENSG00000108774
KO: hsa:5878
Nucleutide sequences
EMBL-CDS: AAM21086.1, AAI06040.1, AAI14440.1, AAB08927.1, CAG46699.1, AAF66594.1, EAW60805.1, AAA74081.1, AAV38291.1, EAW60807.1, EAW60806.1
Gene_ORFName: hCG_2039680
Ensembl_TRS: ENST00000346213, ENST00000547517, ENST00000393860
Protein sequencees
Ensembl_PRO: ENSP00000377440, ENSP00000345689, ENSP00000447053
RefSeq: NP_001238968.1, NP_004574.2, NP_958842.1
Others
UniRef100: UniRef100_P51148
UniRef90: UniRef90_P51148
UniRef50: UniRef50_P20339
UniGene: Hs.650382
CCDS: CCDS11419.1, CCDS58551.1

全选

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