| Type | Description |
|---|---|
| Definition | pre-mRNA processing factor 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 12:18:00 | Results confirmed that the PRPF4 gene was overexpressed in various breast cancer cell lines. Its knockdown slows down breast cancer progression via suppression of p38 MAPK phosphorylation. In conclusion, the PRPF4 gene plays an important role in the growth of breast cancer cells. | 31445970 |
| 2019-06-01 12:26:00 | Possible molecular mechanism of PRP4-induced actin cytoskeleton remodeling and epithelial-mesenchymal transition, makes PRP4 an important target in colon cancer. | 29787735 |
| 2015-07-25 10:58:00 | The p.R192H variant of PRPF4 represents a functional null allele which compromises the function of the tri-snRNP, reinforcing the notion that this spliceosomal particle is of crucial importance in the physiology of the retina. | 25383878 |
| 2015-01-17 12:37:00 | PRPF4 missense mutations is associated with autosomal dominant retinitis pigmentosa. | 24419317 |
| 2014-01-04 12:38:00 | the requirement of enzymatic activity of PRP4 in regulating cancer cell growth and identified an array of potential novel substrates through orthogonal proteomics approaches | 24003220 |
| Type | IDs |
|---|---|
| Synonymous | HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60 |
| Gene |
UniProtKB-ID:
PRP4_HUMAN,
Q5T1M7_HUMAN
UniprotKB:
O43172,
Q5T1M7
UniParc:
UPI0000132340,
UPI000002B1A2
EMBL:
BC001588,
AF016369,
AL449305,
U82756,
CH471090,
AY572489,
BC007424,
AF001687
Ensembl:
ENSG00000136875
KO:
hsa:9128
|
| Nucleutide sequences |
EMBL-CDS:
EAW87362.1,
AAC51925.1,
AAC02261.1,
AAB87640.1,
AAH07424.1,
AAH01588.1,
AAS78572.1,
EAW87363.1
Gene_ORFName:
hCG_29193
Ensembl_TRS:
ENST00000374198,
ENST00000374199
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363313,
ENSP00000363315
RefSeq:
NP_004688.2,
NP_001231855.1,
NP_001309196.1,
NP_001309195.1
|
| Others |
UniRef100:
UniRef100_O43172,
UniRef100_Q5T1M7
UniRef90:
UniRef90_O43172
UniRef50:
UniRef50_O43172
UniGene:
Hs.744014
CCDS:
CCDS59142.1,
CCDS6791.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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