| Type | Description |
|---|---|
| Definition | MCTS1 re-initiation and release factor |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 11:46:00 | These results suggest MCT-1/miR-34a/IL-6/IL-6R axis is responsible for MCT-1-mediated effects on non-small cell lung cance cell stemness. | 31891569 |
| 2019-08-03 10:17:00 | High MCT-1 expression is associated with M2-like polarization and triple-negative breast cancer cell invasion. | 30885232 |
| 2019-04-27 10:18:00 | Present the crystal structure of MCTS1 bound to a fragment of DENR. Based on this structure, we identify and experimentally validate that DENR residues Glu42, Tyr43, and Tyr46 are important for MCTS1 binding and that MCTS1 residue Phe104 is important for tRNA binding. Mutation of these residues reveals that DENR-MCTS1 dimerization and tRNA binding are both necessary for DENR and MCTS1 to promote translation reinitiation. | 29889857 |
| 2019-03-16 10:16:00 | findings elucidate further the mechanism of regulation of DENR-MCT-1 activities in unconventional translation initiation, reinitiation, and recycling. | 30584092 |
| 2018-11-03 11:13:00 | inhibitor sotrastaurin induced cell apoptosis and cell cycle arrest in DLBCL cells potentially through regulating the expression of MCT-1 | 29534146 |
| Type | IDs |
|---|---|
| Synonymous | MCT-1, MCT1 |
| Gene |
UniProtKB-ID:
MCTS1_HUMAN
UniprotKB:
Q9ULC4
UniParc:
UPI000178DE66,
UPI0000211E58,
UPI000006E770
EMBL:
AB034206,
CH471107,
BC095461,
AC011890,
AY364258,
AK311993,
AK294834,
BC001013
Ensembl:
ENSG00000288295,
ENSG00000232119
KO:
hsa:28985
|
| Nucleutide sequences |
EMBL-CDS:
AAQ76817.1,
AAH95461.1,
BAG34931.1,
BAG57943.1,
EAX11874.1,
BAA86055.1,
AAH01013.1
Ensembl_TRS:
ENST00000371317,
ENST00000371315,
ENST00000672136,
ENST00000673335
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360365,
ENSP00000360367,
ENSP00000500508,
ENSP00000500610
RefSeq:
NP_001131026.1,
NP_054779.1
|
| Others |
UniRef100:
UniRef100_Q9ULC4
UniRef90:
UniRef90_Q9ULC4
UniRef50:
UniRef50_Q9ULC4
UniGene:
Hs.102696,
Hs.670803
CCDS:
CCDS48160.1,
CCDS14601.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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