| Type | Description |
|---|---|
| Definition | phosphohistidine phosphatase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 10:27:00 | Our study reveals the important role of PHP14 in regulating hepatic stellate cell migration in liver fibrosis | 29098317 |
| 2018-09-15 11:08:00 | In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +/- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +/- 1 and 490 +/- 20 muM | 29630837 |
| 2018-08-18 10:06:00 | High PHPT1 expression is associated with cancer. | 29787434 |
| 2017-02-18 10:49:00 | H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. Molecular dynamics simulations suggest that if Met95 oxidation alters hPHPT1 activity, then it will do so by altering the stability of an intermediate state. Mass spectrometry showed that H2O2-induced oxidation does not impact hPHPT1 function negatively. | 27034094 |
| 2016-09-24 12:09:00 | PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma tissue samples. | 26537769 |
| Type | IDs |
|---|---|
| Synonymous | CGI-202, HEL-S-132P, HSPC141, PHP, PHP14 |
| Gene |
UniProtKB-ID:
PHP14_HUMAN,
V9HWC4_HUMAN
UniprotKB:
Q9NRX4,
V9HWC4
UniParc:
UPI0000034027,
UPI000046FF07
EMBL:
CH471090,
AL355987,
EU794646,
AF393504,
BC024648,
AF285119,
BQ922335,
AF164795,
AL136644
Ensembl:
ENSG00000054148
KO:
hsa:29085
|
| Nucleutide sequences |
EMBL-CDS:
EAW88289.1,
AAG01156.1,
AAH24648.1,
CAB66579.1,
AAN52504.1,
AAF80759.1,
EAW88291.1,
ACJ13700.1
Gene_ORFName:
CGI-202,
HSPC141,
hCG_2021985
Ensembl_TRS:
ENST00000371661,
ENST00000247665
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360724,
ENSP00000247665
RefSeq:
NP_001129333.1,
NP_001274271.1,
NP_001274272.1,
NP_054891.2
|
| Others |
UniRef100:
UniRef100_Q9NRX4
UniRef90:
UniRef90_Q9NRX4
UniRef50:
UniRef50_Q9NRX4
UniGene:
Hs.409834
CCDS:
CCDS48060.1,
CCDS7009.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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