| Type | Description |
|---|---|
| Definition | isoleucyl-tRNA synthetase 2, mitochondrial |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 12:00:00 | IARS2 knockdown can inhibit acute myeloid leukemia HL-60 cell proliferation and cause cell cycle arrest at the G1 phase by regulating the p53/p21/PCNA/eIF4E pathways. | 30832756 |
| 2018-12-22 10:04:00 | IARS2 silencing induced NSCLC cells growth inhibition, cell cycle arrest and promoted cell apoptosis | 26639235 |
| 2017-03-11 12:40:00 | Patients with this very rare mutation present with a myriad of ocular findings, including infantile cataract, neurotrophic keratitis, corneal opacification, and orbital myopathy. | 27078007 |
| 2016-10-22 11:31:00 | The expression of IARS2 gene is different in human colon cancer and surrounding tissues. IARS2 gene is probably a cancer-promoting gene | 26722399 |
| 2015-08-01 11:01:00 | This study is the first report of clinical findings associated with IARS2 mutations. | 25130867 |
| Type | IDs |
|---|---|
| Synonymous | CAGSSS, ILERS |
| Gene |
UniProtKB-ID:
SYIM_HUMAN
UniprotKB:
Q9NSE4
UniParc:
UPI000035B256
EMBL:
BC047880,
D28500,
BC010218,
CH471100,
BC040376,
AK001188,
BC137438,
AK022665,
AY267462,
AC103590
Ensembl:
ENSG00000067704
KO:
hsa:55699
|
| Nucleutide sequences |
EMBL-CDS:
AAH10218.2,
AAH47880.3,
EAW93305.1,
AAH40376.2,
AAI37439.1,
BAB14164.1,
AAP94033.1,
BAA95147.1,
BAA91544.1
Ensembl_TRS:
ENST00000366922
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355889
RefSeq:
NP_060530.3
|
| Others |
UniRef100:
UniRef100_Q9NSE4
UniRef90:
UniRef90_Q9NSE4
UniRef50:
UniRef50_Q9NSE4
UniGene:
Hs.262823
CCDS:
CCDS1523.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员