| Type | Description |
|---|---|
| Definition | Mtr4 exosome RNA helicase |
| Date | Results | Publications |
|---|---|---|
| 2020-09-12 16:05:00 | Mapping domains of ARS2 critical for its RNA decay capacity. | 32463452 |
| 2020-05-16 12:45:00 | MTR4 is required for the tumorigenesis of the hepatocellular carcinoma cells.MTR4 is a mediator of the functions of c-Myc in cancer metabolism.MTR4 drives cancer metabolism by ensuring correct alternative splicing of pre-mRNAs of critical glycolytic genes such as GLUT1 and PKM2. | 32024842 |
| 2020-01-04 10:06:00 | Data show that the nuclear exosome adaptors nuclear valosin-containing protein-like (NVL) and zinc finger, CCHC domain containing 8 protein (ZCCHC8) bind the Mtr4 exosome RNA helicase (MTR4) KOW domain on a surface. | 31358741 |
| 2019-07-06 12:41:00 | NRDE2 interacts with MTR4's key residues, locks MTR4 in a closed conformation, and inhibits MTR4 interaction with the exosome as well as proteins important for MTR4 recruitment | 30842217 |
| 2018-12-22 12:12:00 | The cryo-EM structure of the holo-complex shows how obligate nuclear cofactors position the hMTR4 helicase at the entrance of the core complex, suggesting a striking structural conservation from lower to higher eukaryotes. | 30047866 |
| Type | IDs |
|---|---|
| Synonymous | Dob1, KIAA0052, Mtr4, SKIV2L2, fSAP118 |
| Gene |
UniProtKB-ID:
MTREX_HUMAN,
Q3MHC9_HUMAN
UniprotKB:
P42285,
Q3MHC9
UniParc:
UPI00005B72E9,
UPI000020C772
EMBL:
D29641,
BC104996,
BC065258,
BX640789,
BC105291,
BC113509,
BC031779,
BC014669,
BC028604
Ensembl:
ENSG00000039123
KO:
hsa:23517
|
| Nucleutide sequences |
EMBL-CDS:
CAE45877.1,
AAH65258.1,
AAI04997.1,
AAI13510.1,
AAH28604.3,
BAA06124.2,
AAH14669.2,
AAH31779.1,
AAI05292.1
Ensembl_TRS:
ENST00000230640
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000230640
RefSeq:
NP_056175.3
|
| Others |
UniRef100:
UniRef100_Q3MHC9,
UniRef100_P42285
UniRef90:
UniRef90_P42285,
UniRef90_Q3MHC9
UniRef50:
UniRef50_Q3MHC9,
UniRef50_P42285
UniGene:
Hs.274531
CCDS:
CCDS3967.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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