| Type | Description |
|---|---|
| Definition | pyruvate dehydrogenase E1 beta subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-03-23 11:01:00 | Building on evidence that PDH activity depends on the stability of a multi-protein PDH complex, the authors found that the PDH-E1beta subunit of the PDH complex is downregulated to inhibit PDH activity under conditions of prolonged hypoxia which establishs the specific mechanism through which PDH acts as an oncogenic factor by tuning glycolytic metabolism in cancer cells. | 29436427 |
| 2017-02-18 10:26:00 | PDHB was downregulated in nasopharyngeal carcinoma cells. Forced expression of PDHB in NPC cells inhibited cell growth and migration, while knocking down the expression of PDHB promoted the growth, migration, and tumorigenesis of NPC cells. PDHB inhibited ERK signaling and cell growth driven by RasV12. | 26857147 |
| 2015-06-27 10:22:00 | Data indicate that (pro)renin receptor ATP6PA2 interacts with the E1 beta subunit of pyruvate dehydrogenase and controlling its protein stability | 25720494 |
| 2014-10-25 12:41:00 | PHD3 depletion did not affect the expression of the PDH-E1alpha, E1beta, and E2 subunits, or the phosphorylation status of E1alpha, but destabilized the PDH complex (PDC), resulting in less functional PDC. | 25088999 |
| 2013-08-10 12:07:00 | Sequencing of PDHB reveals a homozygous point mutation (c.302T>C), causing a predicted amino acid change in patient 1. Patient 2 is compound heterozygote for mutations c.301A>G (p.M101V) and c.313G>A (p.R105Q). | 19924563 |
| Type | IDs |
|---|---|
| Synonymous | PDHBD, PDHE1-B, PDHE1B, PHE1B |
| Gene |
UniProtKB-ID:
ODPB_HUMAN,
A0A384MDR8_HUMAN
UniprotKB:
P11177,
A0A384MDR8
UniParc:
UPI000013E81D,
UPI00017A6C8D,
UPI000006D611
EMBL:
M34056,
D90086,
X57778,
M19123,
M54788,
M34055,
AK313022,
AL117618,
CR541911,
BC001924,
BC000439,
GQ891424,
M34479,
CH471055,
J03576,
AC135507,
AK293153
Ensembl:
ENSG00000168291
KO:
hsa:5162
|
| Nucleutide sequences |
EMBL-CDS:
CAB56017.1,
BAA14123.1,
AAH01924.1,
AAA60233.1,
BAG35857.1,
AAA60052.1,
CAA40924.1,
BAG56698.1,
AAA88097.1,
EAW65371.1,
CAG46709.1,
AAH00439.1,
AAA60054.1,
AAA36428.1,
AAA60053.1,
ADO22286.1
Ensembl_TRS:
ENST00000485460,
ENST00000383714,
ENST00000302746
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000373220,
ENSP00000307241,
ENSP00000417267
RefSeq:
NP_001166939.1,
NP_001302465.1,
NP_000916.2
|
| Others |
UniRef100:
UniRef100_P11177
UniRef90:
UniRef90_P11177
UniRef50:
UniRef50_P11177
UniGene:
Hs.161357
CCDS:
CCDS82795.1,
CCDS2890.1,
CCDS54602.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员