| Type | Description |
|---|---|
| Definition | RuvB like AAA ATPase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:33:00 | Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. | 33205750 |
| 2021-02-06 13:55:00 | NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis. | 33367824 |
| 2020-05-30 12:57:00 | These data demonstrate that RUVBL2 is essential for the oncogenic function of c-MYB in AML by governing inhibition of myeloid differentiation. They also indicate that targeting the control of c-MYB function by RUVBL2 is a promising approach to developing future anti-AML therapies. | 31138842 |
| 2020-02-22 12:13:00 | We identify RUVBL1 and RUVBL2 as novel interactors of Ebola virus NP and EBOV NP recruitment of the R2TP complex, which may provide novel targets for broad-acting anti-EBOV therapeutics. | 31018511 |
| 2019-11-09 11:00:00 | Analytical ultracentrifugation and cryo electron microscopy analyses performed on hsRuvBL2 highlight an oligomer plasticity that possibly reflects different physiological conformations of the protein in the cell, as well as that single-stranded DNA (ssDNA) can promote the oligomerization of monomeric hsRuvBL2. | 30213962 |
| Type | IDs |
|---|---|
| Synonymous | CGI-46, ECP-51, ECP51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B |
| Gene |
UniProtKB-ID:
RUVB2_HUMAN,
B3KNL2_HUMAN
UniprotKB:
Q9Y230,
B3KNL2
UniParc:
UPI0000044738,
UPI000015F66B,
UPI000049DEC2
EMBL:
BC000428,
AK057498,
BC004531,
AF124607,
AK074542,
AF155138,
CH471177,
AL136743,
AK027762,
BC008355,
Y18417,
AC008687,
CR533507,
AF151804,
AB024301
Ensembl:
ENSG00000183207
KO:
hsa:10856
|
| Nucleutide sequences |
EMBL-CDS:
AAH00428.1,
BAA76708.1,
AAH08355.1,
BAG51921.1,
AAD38073.1,
AAD34041.1,
CAB46270.1,
EAW52430.1,
AAH04531.1,
CAG38538.1,
CAB66677.1,
AAF87087.1,
EAW52426.1,
BAC11048.1,
EAW52429.1,
BAG51374.1
Gene_ORFName:
CGI-46,
hCG_16214
Ensembl_TRS:
ENST00000595090
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000473172
RefSeq:
NP_006657.1,
NP_001308120.1,
NP_001308119.1,
XP_011524632.1
|
| Others |
UniRef100:
UniRef100_B3KNL2,
UniRef100_Q9Y230
UniRef90:
UniRef90_Q9Y230,
UniRef90_A0A5G2RC74
UniRef50:
UniRef50_Q9Y230
UniGene:
Hs.515846
CCDS:
CCDS42588.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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