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63893 UBE2O

63893

UBE2O

ubiquitin conjugating enzyme E2 O

protein-coding

Homo sapiens

基因描述

Type Description
Definition ubiquitin conjugating enzyme E2 O

研究结论

Date Results Publications
2021-02-02 13:25:00 Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6. 32375794
2021-01-16 15:57:00 UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKalpha2/mTORC1-MYC positive feedback loop. 31907353
2020-07-25 12:03:00 Study found that UBE2O is markedly upregulated in obese subjects with type 2 diabetes. 31292296
2020-05-09 12:57:00 UBE2O directly mediates the ubiquitination of many substrates, including AMPKalpha2, BAP1, MLL protein SMAD6, c-Maf, ARNTL, and free ribosomal proteins. UBE2O is frequently amplified or mutated in multiple cancers, and its high expression is associated with low survival rate of gastric, lung, breast, and prostate cancer patients. Review. 30468556
2019-05-04 10:08:00 UBE2O is critical for P-TEFb recruitment to the HIV-1 promoter. 29845934

名称对应

Type IDs
Synonymous E2-230K
Gene
UniProtKB-ID: UBE2O_HUMAN
UniprotKB: Q9C0C9
UniParc: UPI000020032F
EMBL: AL832432, BC036820, AK025999, BC004525, AB051521, CH471099, AK022940, BC025977, BC051868, AK024657, AC090699, BC022237
Ensembl: ENSG00000175931
KO: hsa:63893
Nucleutide sequences
EMBL-CDS: BAB14948.1, AAH36820.1, BAB14320.1, BAB21825.1, AAH04525.2, CAH10644.1, EAW89396.1, BAB15313.1, AAH25977.1, AAH22237.1, AAH51868.2
Ensembl_TRS: ENST00000319380
Protein sequencees
Ensembl_PRO: ENSP00000323687
RefSeq: XP_024306633.1, XP_005257624.1, NP_071349.3, XP_016880424.1, XP_024306635.1, XP_024306634.1
Others
UniRef100: UniRef100_Q9C0C9
UniRef90: UniRef90_Q9C0C9
UniRef50: UniRef50_Q9C0C9
UniGene: Hs.16130
CCDS: CCDS32742.1

全选

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