| Type | Description |
|---|---|
| Definition | nicotinate phosphoribosyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 12:58:00 | Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. | 31268507 |
| 2020-01-04 10:10:00 | Study demonstrated that PPM1D mutant astrocytes and patient-derived PPM1D mutant diffuse intrinsic pontine glioma lines are particularly sensitive to treatment with NAMPT inhibitors. Mutant PPM1D-induced NAMPT inhibitor sensitivity is driven by hypermethylation of CpG islands throughout the genome and the epigenetic silencing of NAPRT, a key gene involved in NAD biosynthesis. | 31439867 |
| 2019-12-28 12:15:00 | these data identify NAPRT as a endogenous ligand for TLR4 and a mediator of inflammation. | 31511522 |
| 2018-07-14 10:08:00 | No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma | 28860121 |
| 2017-07-08 12:40:00 | Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases | 28416276 |
| Type | IDs |
|---|---|
| Synonymous | NAPRT1, PP3856 |
| Gene |
UniProtKB-ID:
PNCB_HUMAN
UniprotKB:
Q6XQN6
UniParc:
UPI00016277E0,
UPI000020FE82,
UPI000058EC33
EMBL:
AY214326,
BC006284,
AB242230,
AY214327,
BC032466,
AY214325
Ensembl:
ENSG00000147813,
ENSG00000278488
KO:
hsa:93100
|
| Nucleutide sequences |
EMBL-CDS:
BAF75377.1,
AAP69605.1,
AAP69603.1,
AAH32466.1,
AAP69604.1,
AAH06284.2
Ensembl_TRS:
ENST00000621955,
ENST00000426292,
ENST00000449291,
ENST00000632139
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000390949,
ENSP00000488794,
ENSP00000480017,
ENSP00000401508
RefSeq:
XP_016869468.1,
XP_016869464.1,
XP_016869465.1,
NP_001273758.1,
XP_024303101.1,
NP_660202.3,
NP_001350075.1,
XP_024303100.1,
NP_001350074.1,
XP_016869466.1,
XP_016869467.1
|
| Others |
UniRef100:
UniRef100_Q6XQN6
UniRef90:
UniRef90_Q6XQN6
UniRef50:
UniRef50_Q6XQN6
UniGene:
Hs.493164
CCDS:
CCDS6403.2,
CCDS69555.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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