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9646 CTR9

9646

CTR9

CTR9 homolog, Paf1/RNA polymerase II complex component

protein-coding

Homo sapiens

基因描述

Type Description
Definition CTR9 homolog, Paf1/RNA polymerase II complex component

研究结论

Date Results Publications
2019-01-19 10:07:00 Study reports 2.53 A atomic structures of both the human PAF1/CTR9 and yeast Paf1/Ctr9 heterodimers. Results clearly reveal that the heterodimer of PAF1/CTR9 or Paf1/Ctr9 is the core component of evolutionarily conserved multifunctional polymerase-associated factor 1 complex (Paf1C) and is important for human PAF1C or yeast Paf1C assembly, yeast viability, and Paf1C-mediated histone modifications. 30228257
2018-09-08 11:36:00 A novel CTR9 germline variant, located in a consensus splice acceptor site, was found to segregate with Wilms tumor in the family. 29292210
2017-09-02 12:10:00 Our data demonstrated that Ctr9, independent of other PAFc subunits, controls ERalpha-target gene expression by regulating global chromatin occupancies of ERalpha and RNAPII. 27829357
2016-01-30 11:45:00 Ctr9, a key subunit of hPAFc, is a central regulator of estrogen signaling that drives ERalpha(+) breast tumorigenesis 26494790
2015-10-17 11:36:00 Ctr9, formerly identified as a nuclei protein, interacts with the dopamine transporter in the cytoplasmic compartment. 26048990

名称对应

Type IDs
Synonymous SH2BP1, TSBP, p150, p150TSP
Gene
UniProtKB-ID: CTR9_HUMAN
UniprotKB: Q6PD62
UniParc: UPI000006F32A
EMBL: BC058914, D63875, CH471064
Ensembl: ENSG00000198730
KO: hsa:9646
Nucleutide sequences
EMBL-CDS: AAH58914.1, EAW68557.1, BAA09925.2, EAW68558.1
Ensembl_TRS: ENST00000361367
Protein sequencees
Ensembl_PRO: ENSP00000355013
RefSeq: NP_001333208.1, NP_055448.1
Others
UniRef100: UniRef100_Q6PD62
UniRef90: UniRef90_Q62018
UniRef50: UniRef50_Q62018
UniGene: Hs.725151
CCDS: CCDS7805.1

全选

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研究热度

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