| Type | Description |
|---|---|
| Definition | filamin B |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:29:00 | circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response. | 32785098 |
| 2020-01-11 10:58:00 | Studied expression levels of Filamin b (FLN-b) in the placenta of patients with pre-eclampsia (PE). Found down-regulation of FLN-b inhibits the ERK/matrix metallopeptidase 9 (MMP-9) pathways, leading to trophoblastic invasion disorders in the PE placenta. | 30756369 |
| 2019-10-26 12:11:00 | Our report validates key clinical (fused thoracic vertebrae and carpal and tarsal coalition) and molecular (truncating variants in FLNB) characteristics of this condition. | 29566257 |
| 2019-08-03 13:11:00 | These mutations increased binding of FLNB protein to the MAP3K1 and RAC1 signal transduction complex and activated beta-catenin and had different effects on phosphorylation of MAP kinase pathway intermediates and SOX9 expression. Direct activation of beta-catenin through the FLNB-MAP3K1-RAC1 complex by FLNB mutations is a novel mechanism for causing 46,XY gonadal dysgenesis | 29095481 |
| 2019-05-25 12:17:00 | FLNB mutation is associated with Piepkorn type of osteochondrodysplasia. | 29797497 |
| Type | IDs |
|---|---|
| Synonymous | ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, LRS1, SCT, TABP, TAP |
| Gene |
UniProtKB-ID:
FLNB_HUMAN
UniprotKB:
O75369
UniParc:
UPI0001D1474F,
UPI000044714F,
UPI0001AE75A5,
UPI000036716E,
UPI000036716D,
UPI00015E086A,
UPI0001765F91,
UPI00001AEC01,
UPI000036716F
EMBL:
AF191616,
AF191595,
AF238609,
AF191628,
AF191598,
AF191633,
AF191596,
AF191604,
AF191624,
AF042166,
AB371580,
AF191601,
AF191625,
AF191605,
AB209889,
AF043045,
AF191613,
AF191600,
AF191603,
AB371582,
BX641085,
AF191608,
AF191622,
AF191630,
AF353667,
AF191626,
AF191599,
AF191614,
AF353666,
AF191632,
AC114399,
AF191617,
AF191597,
AC137936,
AF191621,
AF191627,
AF191606,
AF191620,
AB371581,
AF191615,
M62994,
AF191619,
AF191602,
AF191607,
AL137574,
AF191610,
AF191609,
AF191611,
AF191629,
AB191258,
AF191631,
AF191594,
AF191612,
AF191618,
AF191623
Ensembl:
ENSG00000136068
KO:
hsa:2317
|
| Nucleutide sequences |
EMBL-CDS:
AAC33845.1,
BAG48309.1,
CAE46040.1,
AAA35505.1,
BAD93126.1,
CAB70818.1,
AAL68441.1,
AAF72339.1,
AAF97046.1,
BAG48311.1,
AAL68439.1,
BAG48310.1,
BAD52434.1,
AAL68443.1,
AAL68442.1,
AAC39842.1,
AAL68440.1
Ensembl_TRS:
ENST00000295956,
ENST00000490882,
ENST00000429972,
ENST00000358537
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000295956,
ENSP00000351339,
ENSP00000420213,
ENSP00000415599
RefSeq:
NP_001157789.1,
NP_001157790.1,
NP_001157791.1,
NP_001448.2
|
| Others |
UniRef100:
UniRef100_O75369
UniRef90:
UniRef90_O75369
UniRef50:
UniRef50_O75369
UniGene:
Hs.476448
CCDS:
CCDS2885.1,
CCDS54601.1,
CCDS54599.1,
CCDS54600.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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