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11075 STMN2

11075

STMN2

stathmin 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition stathmin 2

研究结论

Date Results Publications
2021-02-20 13:36:00 Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. 32790644
2020-03-07 11:08:00 STMN2 is a key regulator functionally connected to known Parkinson's disease risk genes. Network analysis predicts a function of human STMN2 in synaptic trafficking. [Meta-Analysis} 31748532
2019-05-25 11:28:00 premature polyadenylation-mediated reduction in stathmin-2 is a hallmark of ALS-FTD that functionally links reduced nuclear TDP-43 function to enhanced neuronal vulnerability. 30643298
2019-05-25 11:28:00 expression of STMN2, which encodes a microtubule regulator, declined after TDP-43 knockdown and TDP-43 mislocalization as well as in patient-specific motor neurons and postmortem patient spinal cord. STMN2 loss upon reduced TDP-43 function was due to altered splicing, which is functionally important, as we show STMN2 is necessary for normal axonal outgrowth and regeneration. 30643292
2014-12-06 12:15:00 RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. 24414001

名称对应

Type IDs
Synonymous SCG10, SCGN10
Gene
UniProtKB-ID: STMN2_HUMAN
UniprotKB: Q93045
UniParc: UPI0000E21B31, UPI0000000C77
EMBL: AC025599, D50375, S82024, CR456833, AC016240, BQ069488, CH471068, BT020034, AK292737, BC006302
Ensembl: ENSG00000104435
KO: hsa:11075
Nucleutide sequences
EMBL-CDS: AAH06302.1, AAB36428.1, BAF85426.1, AAV38837.1, CAG33114.1, BAA23326.1, EAW87065.1, EAW87064.1
Ensembl_TRS: ENST00000518111, ENST00000220876
Protein sequencees
Ensembl_PRO: ENSP00000429243, ENSP00000220876
RefSeq: NP_001186143.1, NP_008960.2, XP_005251199.1
Others
UniRef100: UniRef100_Q93045
UniRef90: UniRef90_Q93045
UniRef50: UniRef50_Q93045
UniGene: Hs.521651
CCDS: CCDS56542.1, CCDS43748.1

全选

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