| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 48 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-12 14:43:00 | USP48 pathogenic variants are relatively frequent in USP8 wild-type Cushing's disease tumors | 31222332 |
| 2019-07-13 10:10:00 | the catalytic USP domain of USP48 interacts with the N-terminal region of the Rel homology domain (RHD) of RelA. | 30628021 |
| 2019-01-12 11:25:00 | USP48 and BRAF mutations have a role in Cushing's disease | 30093687 |
| 2018-12-22 10:04:00 | USP48 inactivation reduces chromosomal instability of Fanconi anemia (FA)-defective cells. Our results highlight a role for USP48 in controlling DNA repair and suggest it as a potential target that could be therapeutically exploited for FA. | 29891926 |
| 2018-11-10 12:12:00 | In contrast to other deubiquitinating enzymes (DUBs) that have been previously implicated in the regulation of Mdm2 protein stability, USP48 did not induce Mdm2 stabilization by significantly reducing Mdm2 ubiquitination levels. | 28233861 |
| Type | IDs |
|---|---|
| Synonymous | RAP1GA1, USP31 |
| Gene |
UniProtKB-ID:
UBP48_HUMAN
UniprotKB:
Q86UV5
UniParc:
UPI000004381C,
UPI00003711C7,
UPI0000070764,
UPI000006F149,
UPI000189A7F4,
UPI0000192195,
UPI0000204630,
UPI00002326F6
EMBL:
BC067261,
AK000110,
BC103724,
AL834375,
AL359815,
BC104896,
BC013567,
AL590103,
BC007326,
AK002190,
AK026930,
BC143354,
AK026707,
AF502942
Ensembl:
ENSG00000090686
KO:
hsa:84196
|
| Nucleutide sequences |
EMBL-CDS:
AAI43355.1,
BAB15591.1,
BAA92128.1,
BAA90950.1,
CAD39038.1,
AAI03725.1,
AAH67261.1,
AAH13567.1,
AAI04897.1,
BAB15533.1,
AAH07326.2,
AAP30832.1
Ensembl_TRS:
ENST00000308271,
ENST00000529637,
ENST00000400301,
ENST00000421625
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000431949,
ENSP00000383157,
ENSP00000406256,
ENSP00000309262
RefSeq:
NP_001337095.1,
XP_011540566.1,
XP_016857985.1,
XP_016857986.1,
XP_011540569.1,
XP_006711018.1,
NP_001337097.1,
XP_024305935.1,
NP_001317323.1,
XP_011540570.1,
XP_011540567.1,
NP_001027902.1,
NP_115612.4,
NP_001337093.1,
NP_001337096.1
|
| Others |
UniRef100:
UniRef100_Q86UV5
UniRef90:
UniRef90_Q86UV5
UniRef50:
UniRef50_Q86UV5
UniGene:
Hs.467524
CCDS:
CCDS44084.1,
CCDS30623.1,
CCDS81277.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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