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2553 GABPB1

2553

GABPB1

GA binding protein transcription factor subunit beta 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition GA binding protein transcription factor subunit beta 1

研究结论

Date Results Publications
2020-10-31 13:13:00 LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. 31700067
2019-11-09 11:06:00 G allele of (rs7181866 A/G) was found to be significantly associated with risk for obesity among T2DM subjects 30904536
2019-06-29 11:16:00 Study in glioblastoma cells shows that genetic disruption of GABPbeta1L (beta1L), a tetramer-forming isoform of GABP that is dispensable for normal development, results in TERT silencing in a TERT promoter mutation-dependent manner. Reducing TERT expression by disrupting beta1L culminates in telomere loss and cell death exclusively in TERT promoter mutant cells. 30205050
2018-10-27 11:20:00 Data revealed high expression of GABPB1 in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. Its knockdown significantly decreased the colony formation ability via induction of p21Waf/Cip1 expression. Furthermore, the patients at high risk of a poor survival outcome exhibited the highest expression level of GABPB1. These findings imply that GABPB1 serves an important role in the progression of ccRCC. 29845229
2017-11-04 11:58:00 Ectopic overexpression of a dominant-negative acting GABP mutant led to impaired myeloid differentiation of CD34(+) hematopoietic stem/progenitor cells. 27100840

名称对应

Type IDs
Synonymous BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB-1, GABPB2, NRF2B1, NRF2B2
Gene
UniProtKB-ID: GABP1_HUMAN, A0A024R5X6_HUMAN, A0A024R5R5_HUMAN
UniprotKB: Q06547, A0A024R5X6, A0A024R5R5
UniParc: UPI000012AFB3, UPI000002AA2D, UPI000002AA2C, UPI000012AFB4
EMBL: BC036080, U13047, BC050702, D13316, U13045, U13048, U13046, D13317, BT006652, BC016910, CH471082, EU159454
Ensembl: ENSG00000104064
KO: hsa:2553
Nucleutide sequences
EMBL-CDS: AAP35298.1, BAA02573.1, EAW77395.1, AAH16910.1, AAH50702.1, AAA65708.1, AAH36080.1, ABV90874.1, AAA65710.1, BAA02574.1, AAA65709.1, AAA65707.1, EAW77388.1, EAW77394.1, EAW77389.1, EAW77392.1
Gene_ORFName: hCG_2002404, hCG_2002404
Ensembl_TRS: ENST00000396464, ENST00000380877, ENST00000220429, ENST00000429662, ENST00000359031
Protein sequencees
Ensembl_PRO: ENSP00000395771, ENSP00000220429, ENSP00000370259, ENSP00000351923, ENSP00000379728
RefSeq: XP_024305654.1, NP_001307839.1, NP_852092.1, XP_024305656.1, XP_024305652.1, NP_002032.2, XP_024305653.1, XP_011519728.1, XP_016877543.1, NP_001307844.1, NP_057738.1, XP_024305651.1, XP_024305655.1, NP_005245.2, XP_016877542.1, XP_005254331.1, NP_057739.1
Others
UniRef100: UniRef100_Q1RMI3, UniRef100_Q06547, UniRef100_A0A024R5R5
UniRef90: UniRef90_Q00420-2, UniRef90_Q06547
UniRef50: UniRef50_Q00420-2, UniRef50_Q06547
UniGene: Hs.654350
CCDS: CCDS45258.1, CCDS10136.1, CCDS32239.1, CCDS10135.1

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