| Type | Description |
|---|---|
| Definition | formin binding protein 1 like |
| Date | Results | Publications |
|---|---|---|
| 2019-09-14 11:01:00 | During Shigella flexneri infection host protein Toca-1 precipitate not only the Shigella type 3 secreted effector protein IcsB, but also the type 3 secreted proteins OspC3, IpgD and IpaB. In infected cells, OspC3-mediated restriction of IL-18 production does not require the interaction with Toca-1. | 29488864 |
| 2016-12-17 10:44:00 | This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery. | 27129201 |
| 2015-11-14 11:50:00 | Loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease. | 25547174 |
| 2014-10-04 10:25:00 | GWAS results show that the aggregate effects of common SNPs explain 22-46% of phenotypic variation in childhood intelligence in the three largest cohorts; FNBP1L was also significantly associated with childhood intelligence | 23358156 |
| 2013-08-31 11:12:00 | findings suggest that Toca-1 functions at an early step in the dissemination of metastatic breast tumor cells; taken together, results identify Toca-1 as a proinvasive protein in breast adenocarcinoma | 22824798 |
| Type | IDs |
|---|---|
| Synonymous | C1orf39, TOCA1 |
| Gene |
UniProtKB-ID:
FBP1L_HUMAN,
B4DSI7_HUMAN
UniprotKB:
Q5T0N5,
B4DSI7
UniParc:
UPI00017A7AFB,
UPI0000470A36,
UPI000040E45A,
UPI0000237139,
UPI0001B25604,
UPI0000470A35
EMBL:
BC062477,
AY514449,
BC074892,
AL512651,
AK000282,
BC074891,
AL109613,
AK299760,
AC095034
Ensembl:
ENSG00000137942
KO:
hsa:54874
|
| Nucleutide sequences |
EMBL-CDS:
BAA91051.1,
AAH62477.1,
AAH74891.1,
AAH74892.1,
AAR98814.1,
BAG61649.1
Ensembl_TRS:
ENST00000260506,
ENST00000271234,
ENST00000370253
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000260506,
ENSP00000359275,
ENSP00000271234
RefSeq:
XP_011539927.1,
NP_001157945.1,
NP_060207.2,
XP_016857022.1,
NP_001020119.1
|
| Others |
UniRef100:
UniRef100_Q5T0N5
UniRef90:
UniRef90_Q5T0N5
UniRef50:
UniRef50_Q5T0N5
UniGene:
Hs.134060
CCDS:
CCDS60192.1,
CCDS53343.1,
CCDS53344.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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