| Type | Description |
|---|---|
| Definition | cofilin 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 11:31:00 | LncRNA SOX2 overlapping transcript (SOX2-OT) expression was conspicuously elevated in prostate cancer (PC) tissues and cells. Silenced SOX2-OT could repress PC cell proliferation and migration. SOX2-OT bound with miR-369-3p and negatively correlated with miR-369-3p in PC. Cofilin 2 (CFL2) was found to be a downstream target gene of miR-369-3p. | 31623830 |
| 2020-04-11 13:02:00 | These results identify cofilin as a key molecule that may be therapeutically targeted to restore T cell motility necessary for T cell tissue repopulation, immune reconstitution, and immune control of viremia. | 30662943 |
| 2019-12-07 11:28:00 | severe Congenital myopathies related to novel homozygous or compound heterozygous loss-of-function mutations in CFL2, are reported. | 29457652 |
| 2018-11-10 11:59:00 | Here we report atomic-level characterization by magic angle spinning (MAS) NMR of the muscle isoform of human cofilin 2 (CFL2) bound to F-actin. We demonstrate that resonance assignments for the majority of atoms are readily accomplished and we derive the intermolecular interface between CFL2 and F-actin. | 28303963 |
| 2018-09-22 11:48:00 | The secreted levels of the cofilin-2 protein in radioresistant NPC patients were significantly higher than those of radiosensitive cases. | 29664897 |
| Type | IDs |
|---|---|
| Synonymous | NEM7 |
| Gene |
UniProtKB-ID:
COF2_HUMAN,
Q549N0_HUMAN
UniprotKB:
Q9Y281,
Q549N0
UniParc:
UPI0000001236,
UPI0000EE4A3D
EMBL:
AF283513,
BC022364,
AF087867,
AL355885,
AK314157,
BC022876,
AF134803,
CH471078,
BC011444,
AF242299,
AF134802
Ensembl:
ENSG00000165410
KO:
hsa:1073
|
| Nucleutide sequences |
EMBL-CDS:
AAD31280.1,
EAW65912.1,
AAF97934.1,
AAH11444.1,
AAH22364.1,
AAF64498.1,
AAH22876.1,
AAD31281.1,
EAW65911.1,
EAW65910.1,
AAM10495.1,
BAG36842.1,
EAW65908.1
Gene_ORFName:
hCG_21174
Ensembl_TRS:
ENST00000341223,
ENST00000556161,
ENST00000672163,
ENST00000555765,
ENST00000673315,
ENST00000298159,
ENST00000672517
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000452451,
ENSP00000298159,
ENSP00000500002,
ENSP00000452188,
ENSP00000340635,
ENSP00000500375,
ENSP00000500532
RefSeq:
NP_619579.1,
NP_068733.1,
XP_011534665.1,
NP_001230574.1
|
| Others |
UniRef100:
UniRef100_Q9Y281
UniRef90:
UniRef90_Q9Y281
UniRef50:
UniRef50_Q9Y281
UniGene:
Hs.180141
CCDS:
CCDS58311.1,
CCDS9649.1,
CCDS9650.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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