| Type | Description |
|---|---|
| Definition | BUD23 rRNA methyltransferase and ribosome maturation factor |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 10:58:00 | Merm1 is capable of maintaining hypomethylated rRNA gene bodies and co-localizes with RNA polymerase I in the nucleolus. Merm1 interacts with Dnmt3a and represses its methyltransferase activity with the requirement of the binding motif for S-adenosyl-L-methionine. | 30535232 |
| 2019-07-27 10:55:00 | Study results demonstrated that WBSCR22 is involved in colorectal cancer (CRC) resistance to oxaliplatin, suggesting WBSCR22 may represent a novel oxaliplatin resistance biomarker as well as a potential target for CRC therapeutics. | 29133897 |
| 2016-05-07 11:25:00 | The localization of the TRMT112 protein is determined by WBSCR22, and the WBSCR22-TRMT112 complex is localized in the cell nucleus. | 26214185 |
| 2016-03-12 11:11:00 | DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity. | 25851604 |
| 2015-07-25 10:58:00 | Knockdown of Merm1/Wbscr22 attenuates sensitivity of H460 non-small cell lung cancer cells to SN-38 and 5-FU without alteration to p53 expression levels. | 25352209 |
| Type | IDs |
|---|---|
| Synonymous | HASJ4442, HUSSY-3, MERM1, PP3381, WBMT, WBSCR22 |
| Gene |
UniProtKB-ID:
BUD23_HUMAN
UniprotKB:
O43709
UniParc:
UPI0000423E27,
UPI0000138F9B,
UPI000013D676
EMBL:
AK291116,
AF218007,
BC011696,
AK315032,
BC001780,
AC073846,
AF420248,
BC000169,
CH471200,
AJ224442,
AF412034
Ensembl:
ENSG00000071462
KO:
hsa:114049
|
| Nucleutide sequences |
EMBL-CDS:
BAF83805.1,
AAL16066.1,
AAG17249.1,
AAS07473.1,
CAA11944.1,
AAH00169.2,
AAM62316.1,
BAG37517.1,
AAH01780.2,
AAH11696.2,
EAW69657.1
Gene_ORFName:
PP3381,
HUSSY-03
Ensembl_TRS:
ENST00000265758,
ENST00000423497
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000401191,
ENSP00000265758
RefSeq:
XP_011514081.1,
NP_059998.2,
XP_011514080.1,
NP_001189489.1,
XP_006715910.1
|
| Others |
UniRef100:
UniRef100_O43709
UniRef90:
UniRef90_O43709
UniRef50:
UniRef50_O43709
UniGene:
Hs.647063
CCDS:
CCDS5557.1,
CCDS56490.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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