| Type | Description |
|---|---|
| Definition | huntingtin interacting protein K |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 10:09:00 | Huntingtin interacting protein K (HYPK) forms a tetrameric complex with the human N-terminal acetyltransferase E (NatE). HYPK exhibits negative cooperative binding to NAA15 auxiliary subunit by inducing NAA15 shifts in opposing directions. HYPK inhibits NAA10 and NAA50 catalytic activities through structural alteration of the NAA10 and the NatE substrate-binding sites, respectively. | 32042062 |
| 2020-05-02 10:08:00 | Results find the novel mode of internal ribosome entry site (IRES)-dependent translation initiation of HYPK mRNA, along with the determination of mechanism of the nuclear localization process of HYPK. | 31397627 |
| 2019-07-06 12:44:00 | this studu identified the metastable states in the seeds of the Ubiquitin associated (UBA) domain of Huntingtin Interacting Protein K (HYPK). | 30251673 |
| 2019-06-08 10:43:00 | Results find that HYPK harbors intrinsic hNatA-specific inhibitory activity through a bipartite structure: a ubiquitin-associated domain that binds a hNaa15 metazoan-specific region and an N-terminal loop-helix region that distorts the hNaa10 active site. | 29754825 |
| 2018-11-24 12:04:00 | In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity | 28585574 |
| Type | IDs |
|---|---|
| Synonymous | C15orf63, HSPC136 |
| Gene |
UniProtKB-ID:
HYPK_HUMAN,
A0A024R5Q1_HUMAN
UniprotKB:
Q9NX55,
A0A024R5Q1
UniParc:
UPI0001F992C7,
UPI000000D937
EMBL:
AK000438,
AK022435,
AC018512,
CH471082,
AF049613,
AF161485,
BC019262
Ensembl:
ENSG00000242028
KO:
hsa:25764
|
| Nucleutide sequences |
EMBL-CDS:
AAF29100.1,
AAC26849.1,
BAA91165.1,
AAH19262.2,
EAW77241.1,
EAW77242.1
Gene_ORFName:
HSPC136,
hCG_2003792
Ensembl_TRS:
ENST00000442995,
ENST00000406925
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384474,
ENSP00000401155
RefSeq:
NP_001186814.1,
NP_057484.4
|
| Others |
UniRef100:
UniRef100_Q9NX55
UniRef90:
UniRef90_Q9NX55
UniRef50:
UniRef50_Q9NX55
UniGene:
Hs.730672
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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