| Type | Description |
|---|---|
| Definition | ubiquitin conjugating enzyme E2 E1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 10:38:00 | found that critical UBE2E1 residues involved in the capture of the TRIM21 substrate lysine are conserved in ubiquitin-conjugating E2s, whereas residues critical for SUMOylation are not conserved | 31160341 |
| 2019-06-29 11:07:00 | OTUB1 depletion dramatically destabilizes the E2-conjugating enzyme UBE2E1 in both mouse and human OTUB1 knockout cell lines. | 30282802 |
| 2017-12-09 12:50:00 | UBE2E1 expression was adversely correlated with AML survival; UBE2E1 expression was negatively correlated with patients' response to induction chemotherapy | 27855695 |
| 2017-11-25 15:57:00 | IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN. | 28258103 |
| 2017-07-01 12:42:00 | study reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys-119 monoubiquitination | 28073915 |
| Type | IDs |
|---|---|
| Synonymous | UBCH6 |
| Gene |
UniProtKB-ID:
UB2E1_HUMAN,
A0A024R2K3_HUMAN,
B7Z306_HUMAN
UniprotKB:
P51965,
A0A024R2K3,
B7Z306
UniParc:
UPI00001B5787,
UPI0001914CDA,
UPI0000209A7C,
UPI0000137964
EMBL:
AK295354,
AK314854,
AC124914,
X92963,
BC009139,
BI666638,
CH471055,
AC020626,
BI223271
Ensembl:
ENSG00000170142
KO:
hsa:7324
|
| Nucleutide sequences |
EMBL-CDS:
EAW64331.1,
EAW64329.1,
EAW64332.1,
BAG37371.1,
CAA63539.1,
AAH09139.1,
EAW64333.1,
BAH12042.1
Gene_ORFName:
hCG_14891
Ensembl_TRS:
ENST00000424381,
ENST00000306627,
ENST00000346855,
ENST00000467766
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000411351,
ENSP00000303709,
ENSP00000329113,
ENSP00000475890
RefSeq:
NP_872607.1,
NP_001189405.1,
NP_003332.1,
XP_005265488.1
|
| Others |
UniRef100:
UniRef100_P51965,
UniRef100_B7Z306
UniRef90:
UniRef90_A0A2K5PDZ6,
UniRef90_P51965
UniRef50:
UniRef50_A0A2K5PDZ6,
UniRef50_P51965
UniGene:
Hs.164853
CCDS:
CCDS56244.1,
CCDS2639.1,
CCDS2638.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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