| Type | Description |
|---|---|
| Definition | timeless circadian regulator |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:15:00 | Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication. | 32705708 |
| 2021-04-13 10:09:00 | TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer. | 33093451 |
| 2020-03-28 12:56:00 | The mutation prevents TIM accumulation in the nucleus and has altered affinity for CRY2. | 31138685 |
| 2019-10-05 10:36:00 | ERK activation promotes TIMELESS expression in colon cancer cell lines. TIMELESS depletion increases gammaH2AX, a marker of DNA damage, and triggers G2/M arrest via increased CHK1 and CDK1 phosphorylation. | 30629587 |
| 2019-05-18 11:26:00 | Results provide evidence that Timeless displays the characteristics of an ERalpha co-activator: it binds directly to ERalpha, increases its transcriptional activity, and is required for full ERalpha activity. This activity likely contributes to the ability of Timeless to promote breast cancer cell proliferation and may underlie the observed associations between Timeless and breast cancer patient outcome. | 29555554 |
| Type | IDs |
|---|---|
| Synonymous | TIM, TIM1, hTIM |
| Gene |
UniProtKB-ID:
TIM_HUMAN
UniprotKB:
Q9UNS1
UniParc:
UPI0001AE6AD7,
UPI000013C8EA
EMBL:
AF098162,
EU627094,
BC039842,
AB015597,
BC050557,
AC024884
Ensembl:
ENSG00000111602
KO:
hsa:8914
|
| Nucleutide sequences |
EMBL-CDS:
ACD11488.1,
AAH39842.1,
AAC80011.1,
BAA36499.1,
AAH50557.1
Ensembl_TRS:
ENST00000553532,
ENST00000229201
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000450607,
ENSP00000229201
RefSeq:
NP_003911.2,
NP_001317224.1
|
| Others |
UniRef100:
UniRef100_Q9UNS1
UniRef90:
UniRef90_Q9UNS1
UniRef50:
UniRef50_Q9UNS1
UniGene:
Hs.118631
CCDS:
CCDS81699.1,
CCDS8918.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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