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6118 RPA2

6118

RPA2

replication protein A2

protein-coding

Homo sapiens

基因描述

Type Description
Definition replication protein A2

研究结论

Date Results Publications
2021-03-13 13:17:00 Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair. 32856505
2020-11-21 13:12:00 HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation. 31582797
2017-10-07 11:22:00 RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation. 28107649
2017-09-23 11:23:00 Single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit interstrand crossling repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair. 28575657
2017-09-23 11:23:00 E3 ligase RFWD3 functions in timely removal and degradation of RPA and RAD51 to allow homologous recombination progression to subsequent steps following mitomycin C damage. 28575658

名称对应

Type IDs
Synonymous REPA2, RP-A p32, RP-A p34, RPA32
Gene
UniProtKB-ID: RFA2_HUMAN, B4DUL2_HUMAN
UniprotKB: P15927, B4DUL2
UniParc: UPI0000D4C958, UPI000013379F, UPI0000470A73, UPI00002055B5
EMBL: DQ001128, AL109927, J05249, BC021257, CR450348, BC001630, AK300691, BC012157
Ensembl: ENSG00000117748
KO: hsa:6118
Nucleutide sequences
EMBL-CDS: AAH21257.1, AAA36560.1, AAH12157.1, AAX84514.1, AAH01630.1, CAG29344.1, BAG62374.1
Ensembl_TRS: ENST00000373912, ENST00000373909, ENST00000313433
Protein sequencees
Ensembl_PRO: ENSP00000363017, ENSP00000363021, ENSP00000363015
RefSeq: NP_001273005.1, NP_001342058.1, XP_024304630.1, NP_002937.1, NP_001284487.1, XP_024304632.1, NP_001342057.1
Others
UniRef100: UniRef100_P15927-3, UniRef100_P15927
UniRef90: UniRef90_P15927, UniRef90_P15927-3
UniRef50: UniRef50_P15927, UniRef50_P15927-3
UniGene: Hs.79411
CCDS: CCDS314.1, CCDS72740.1

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