| Type | Description |
|---|---|
| Definition | unc-45 myosin chaperone A |
| Date | Results | Publications |
|---|---|---|
| 2020-02-01 10:43:00 | In cells, UNC-45A binds to and destabilizes mitotic spindles, and its depletion causes severe defects in chromosome congression and segregation. UNC-45A is overexpressed in human clinical specimens from chemoresistant ovarian cancer and that UNC-45A-overexpressing cells resist chromosome missegregation and aneuploidy when treated with clinically relevant concentrations of paclitaxel. | 30322860 |
| 2019-10-19 11:01:00 | The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis. | 30737284 |
| 2019-01-26 11:39:00 | A transient induction of the human UNC45-GC, but not UNC45-SM, could rescue the defective endocytosis in these she4Delta cells at 39 degrees C, irrespective of whether they possessed Hsp90alpha or Hsp90beta. | 29288355 |
| 2018-12-22 12:15:00 | Whole-exome sequencing of all affected individuals and their parents identified biallelic mutations in Unc-45 Myosin Chaperone A (UNC45A) as a likely driver for cholestasis, congenital diarrhea, impaired hearing, and bone fragility. | 29429573 |
| 2017-12-09 11:15:00 | UNC-45a promotes generation of contractile actomyosin bundles through synchronized non-muscle myosin II folding and filament-assembly activities. | 29055011 |
| Type | IDs |
|---|---|
| Synonymous | GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A |
| Gene |
UniProtKB-ID:
UN45A_HUMAN
UniprotKB:
Q9H3U1
UniParc:
UPI000006F378,
UPI00000720B1,
UPI000000D953
EMBL:
BC045635,
AK291622,
AL357538,
CH471101,
AB014729,
BC037992,
AB014736,
BC010995,
BC006214,
AK125721,
AL357537
Ensembl:
ENSG00000140553
KO:
hsa:55898
|
| Nucleutide sequences |
EMBL-CDS:
CAB93428.1,
AAH06214.1,
AAH37992.1,
AAH45635.1,
BAB20266.1,
AAH10995.2,
EAX02127.1,
BAB20273.1,
BAG54239.1,
BAF84311.1,
CAB93429.1
Ensembl_TRS:
ENST00000394275,
ENST00000418476
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000377816,
ENSP00000407487
RefSeq:
XP_005255020.1,
NP_001310549.1,
NP_061141.2,
XP_016877896.1,
XP_024305754.1,
XP_011520082.1,
XP_024305753.1,
XP_024305751.1,
NP_001310548.1,
NP_001310550.1,
XP_024305752.1,
NP_001034764.1
|
| Others |
UniRef100:
UniRef100_Q9H3U1
UniRef90:
UniRef90_Q9H3U1
UniRef50:
UniRef50_Q9H3U1
UniGene:
Hs.389461
CCDS:
CCDS10367.1,
CCDS42082.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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