| Type | Description |
|---|---|
| Definition | aconitase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:29:00 | Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy. | 33028849 |
| 2020-09-19 16:31:00 | ACO2 and ANPEP as novel prognostic markers for gallbladder squamous cell/adenosquamous carcinomas and adenocarcinomas. | 32249333 |
| 2020-07-18 11:56:00 | This work identifies ACO2 as a relevant gene in cancer metabolic rewiring of MCF-7 cells, promoting a different utilisation of pyruvate and revealing the potential metabolic vulnerability of ACO2-associated malignancies. | 31819175 |
| 2020-06-13 11:55:00 | Study showed that the expression of ACO2 was significantly increased in prostate cancer (PC) tissues and identified a positive correlation between ACO2 expression and the malignancy of prostate cancer. ACO2 protein expression and activity was higher in paclitaxel-resistant PC3 cells than in PTX-sensitive DU145 cells. These results indicate that ACO2 plays an important role in the development and drug resistance of PC. | 30972978 |
| 2020-05-30 10:04:00 | The study provides the most extensive cohort of patients and further delineates the clinical, radiological, biochemical, and molecular features of ACO2 deficiency. | 30689204 |
| Type | IDs |
|---|---|
| Synonymous | ACONM, HEL-S-284, ICRD, OCA8, OPA9 |
| Gene |
UniProtKB-ID:
ACON_HUMAN
UniprotKB:
Q99798
UniParc:
UPI000003CA3B
EMBL:
BC014092,
U87933,
U87930,
U87931,
U87938,
U87936,
U87926,
U87935,
BC026196,
AL008582,
U80040,
U87934,
AL023553,
CR456365,
U87937,
U87929,
CR536568,
U87928,
U87927,
U87939,
U87932
Ensembl:
ENSG00000100412
KO:
hsa:50
|
| Nucleutide sequences |
EMBL-CDS:
AAH14092.1,
AAC39921.1,
AAB38416.1,
CAG30251.1,
AAH26196.1,
CAG38805.1
Ensembl_TRS:
ENST00000216254
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000216254
RefSeq:
NP_001089.1,
XP_016884301.1,
XP_024308018.1
|
| Others |
UniRef100:
UniRef100_Q99798
UniRef90:
UniRef90_Q99798
UniRef50:
UniRef50_Q99798
UniGene:
Hs.643610
CCDS:
CCDS14017.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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