| Type | Description |
|---|---|
| Definition | DDRGK domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-06-08 12:24:00 | UFBP1 expression downregulates the protein level and reduces the stability of several of its interacting proteins; promotes their ubiquitination and degradation | 29533670 |
| 2018-12-22 10:09:00 | Study results provide evidence that DDRGK1 is essential for endoplasmic reticulum (ER) homeostasis regulation in both human cancer cells and mouse hematopoietic stem cells. Depletion of DDRGK1 activates apoptotic pathway by targeting the ER-stress sensor IRE1alpha. DDRGK1 regulates IRE1alpha protein stability via its interaction with the kinase domain of IRE1alpha. | 28128204 |
| 2018-11-17 10:55:00 | Prognostic analysis showed that the co-expression of CDK5RAP3 and DDRGK1 was an independent prognostic factor correlating with the overall survival of gastric cancer patients. | 30228783 |
| 2018-08-04 12:05:00 | we screened the susceptibility loci for Myocardial infarction (MI) using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. | 29321365 |
| 2017-09-16 12:50:00 | Loss of DDRGK1 decreases SOX9 expression and causes a human skeletal dysplasia. | 28263186 |
| Type | IDs |
|---|---|
| Synonymous | C20orf116, SEMDSH, UFBP1, dJ1187M17.3 |
| Gene |
UniProtKB-ID:
DDRGK_HUMAN
UniprotKB:
Q96HY6
UniParc:
UPI00001D47C4,
UPI0000001C9A
EMBL:
BC011851,
CH471133,
BC000643,
AL121891,
BC007957
Ensembl:
ENSG00000198171
KO:
hsa:65992
|
| Nucleutide sequences |
EMBL-CDS:
AAH11851.1,
AAH07957.1,
EAX10544.1,
AAH00643.1
Ensembl_TRS:
ENST00000354488
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000346483
RefSeq:
NP_076424.1
|
| Others |
UniRef100:
UniRef100_Q96HY6
UniRef90:
UniRef90_Q96HY6
UniRef50:
UniRef50_Q96HY6
UniGene:
Hs.471975
CCDS:
CCDS13050.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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