| Type | Description |
|---|---|
| Definition | Sec23 homolog B, coat complex II component |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:07:00 | Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis. | 32123160 |
| 2021-02-20 13:36:00 | RAP-011 Rescues the Disease Phenotype in a Cellular Model of Congenital Dyserythropoietic Anemia Type II by Inhibiting the SMAD2-3 Pathway. | 32759740 |
| 2019-05-18 11:43:00 | Here, the authors show that the F-box protein FBXW5 targets SEC23B, a component of COPII, for proteasomal degradation and that this event limits the autophagic flux in the presence of nutrients. In response to starvation, ULK1 phosphorylates SEC23B on Serine 186, preventing the interaction of SEC23B with FBXW5 and, therefore, inhibiting SEC23B degradation. | 30596474 |
| 2019-03-16 11:06:00 | mutant SEC23B binds to UBF transcription factor, with increased UBF transcription factor binding at the ribosomal DNA promoter. Our data indicate SEC23B has potential non-canonical COPII-independent function, particularly within the ribosome biogenesis pathway, and that may contribute to the pathogenesis of cancer-predisposition. | 29893852 |
| 2018-11-10 11:20:00 | A Y462C mutation was found in 5 members of a consanguineous Indian family. In the homozygous patient, it resulted in congenital dyserythropoietic anemia type II. | 28879554 |
| Type | IDs |
|---|---|
| Synonymous | CDA-II, CDAII, CDAN2, CWS7, HEMPAS, hSec23B |
| Gene |
UniProtKB-ID:
SC23B_HUMAN,
A0A2R8YFH5_HUMAN
UniprotKB:
Q15437,
A0A2R8YFH5
UniParc:
UPI0001C552C9,
UPI0000135455
EMBL:
AL121900,
BC005404,
BC095404,
AL121893,
CH471133,
BC005032,
X97065
Ensembl:
ENSG00000101310
KO:
hsa:10483
|
| Nucleutide sequences |
EMBL-CDS:
AAH95404.1,
CAA65775.1,
EAX10232.1,
EAX10235.1,
EAX10231.1,
EAX10233.1,
EAX10234.1,
AAH05404.1,
AAH05032.1
Ensembl_TRS:
ENST00000336714,
ENST00000650089,
ENST00000262544,
ENST00000377465,
ENST00000643747
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000497473,
ENSP00000338844,
ENSP00000366685,
ENSP00000262544,
ENSP00000496460
RefSeq:
NP_116780.1,
XP_016883082.1,
NP_001166217.1,
NP_001166216.1,
NP_006354.2,
NP_116781.1
|
| Others |
UniRef100:
UniRef100_Q15437,
UniRef100_A0A2R8YFH5
UniRef90:
UniRef90_Q15437
UniRef50:
UniRef50_Q15436
UniGene:
Hs.369373
CCDS:
CCDS13137.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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