| Type | Description |
|---|---|
| Definition | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:43:00 | PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2. | 32632107 |
| 2021-01-23 13:00:00 | Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target. | 32571877 |
| 2020-09-12 16:01:00 | Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. | 31624245 |
| 2019-03-09 10:44:00 | PAICS is hypomethylated in the lung adenocarcinoma tissues.PAICS is highly expressed in the lung adenocarcinoma tissues. | 30641222 |
| 2018-12-01 11:25:00 | we show that PAICS, which catalyzes a critical step in purine biosynthetic pathway, is overexpressed and plays a role in BLCA cell proliferation, colony formation, and 3D spheroid invasion, suggesting a role in oncogenesis. | 30121007 |
| Type | IDs |
|---|---|
| Synonymous | ADE2, ADE2H1, AIRC, PAIS |
| Gene |
UniProtKB-ID:
PUR6_HUMAN
UniprotKB:
P22234
UniParc:
UPI0000E9B4A6,
UPI0000132A76
EMBL:
BC019255,
BC010273,
CR749824,
AC068620,
X53793,
BT006988,
AC114766
Ensembl:
ENSG00000128050
KO:
hsa:10606
|
| Nucleutide sequences |
EMBL-CDS:
AAH10273.1,
AAH19255.1,
CAH18683.1,
CAA37801.1,
AAP35634.1
Ensembl_TRS:
ENST00000399688,
ENST00000264221,
ENST00000512576
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000382595,
ENSP00000264221,
ENSP00000421096
RefSeq:
NP_006443.1,
NP_001072992.1,
NP_001072993.1,
XP_011532668.1
|
| Others |
UniRef100:
UniRef100_P22234
UniRef90:
UniRef90_P22234
UniRef50:
UniRef50_P22234
UniGene:
Hs.518774,
Hs.709570
CCDS:
CCDS47060.1,
CCDS47061.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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