| Type | Description |
|---|---|
| Definition | nicastrin |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:33:00 | NCSTN promotes hepatocellular carcinoma cell growth and metastasis via beta-catenin activation in a Notch1/AKT dependent manner. | 32631394 |
| 2019-11-02 10:58:00 | The impaired EGFR signaling and its effects on epidermal differentiation were also observed in familial AI patients and Ncstn(DeltaKC) mice. Thus, our study showed that miR-30a-3p/RAB31/EGFR signaling pathway may play a key role in the pathogenesis of familial AI with NCSTN mutations. | 30120935 |
| 2019-05-18 10:30:00 | A heterozygous nonsense mutation (c.617C>A, p.S206X) was identified in NCSTN in the proband. This mutation in NCSTN also existed in the other AI patients but not in the two normal relatives and 50 control subjects. | 30105992 |
| 2018-12-22 11:33:00 | Identification of a novel deletion mutation in exon 4 of NCSTN, which may underlie the molecular pathogenesis in this Acne inversa family. | 30030622 |
| 2018-12-01 11:45:00 | A physical interaction between nicastrin (hNCT) and the gamma-secretase substrate amyloid beta-protein precursor (APPC100) confirmed the functionality of hNCT as a substrate recognizer. | 28276527 |
| Type | IDs |
|---|---|
| Synonymous | ATAG1874 |
| Gene |
UniProtKB-ID:
NICA_HUMAN,
B4DR82_HUMAN
UniprotKB:
Q92542,
B4DR82
UniParc:
UPI00017A7ADD,
UPI00001D47D0,
UPI0000042050
EMBL:
AK314764,
D87442,
AK299142,
AY359120,
AL445230,
AF240468,
CH471121,
BC047621
Ensembl:
ENSG00000162736
KO:
hsa:23385
|
| Nucleutide sequences |
EMBL-CDS:
AAH47621.1,
AAQ89478.1,
EAW52721.1,
EAW52720.1,
EAW52722.1,
AAG11412.1,
BAG37302.1,
BAA13383.1,
BAG61194.1
Gene_ORFName:
UNQ1874/PRO4317
Ensembl_TRS:
ENST00000294785
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000294785
RefSeq:
NP_001277115.1,
XP_005245110.1,
NP_056146.1,
NP_001336658.1,
NP_001277113.1
|
| Others |
UniRef100:
UniRef100_Q92542,
UniRef100_B4DR82
UniRef90:
UniRef90_Q92542,
UniRef90_H0WIR7
UniRef50:
UniRef50_Q92542
UniGene:
Hs.517249
CCDS:
CCDS1203.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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