| Type | Description |
|---|---|
| Definition | inverted formin, FH2 and WH2 domain containing |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | Multiple formin proteins participate in glioblastoma migration. | 32727404 |
| 2020-09-05 13:56:00 | FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes. | 31924668 |
| 2020-05-16 12:44:00 | Study used lysine-to-glutamine mutations to map the relevant lysines on actin for INF2 regulation. K50Q- and K61Q-actin, when bound to CAP2, inhibit full-length INF2 but not INF2 lacking inhibitory domain (DID). CAP WH2 domain binds INF2-DID with submicromolar affinity but has weak affinity for actin monomers, while INF2-C-terminal diaphanous autoregulatory domain binds CAP/K50Q-actin 5-fold better than CAP/WT-actin. | 31871199 |
| 2020-01-18 12:05:00 | our results indicated that oxidative stress-mediated HaCaT cells apoptosis could be reversed by Tan IIA treatment via reducing INF2-related mitochondrial stress in a manner dependent on the ERK signaling pathway. | 31354004 |
| 2019-09-28 12:04:00 | The phenotypic feature of the pedigree is autosomal dominant intermediate Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis, which may be attributed to the c.341G>A mutation of the INF2 gene. | 31515790 |
| Type | IDs |
|---|---|
| Synonymous | C14orf151, C14orf173, CMTDIE, FSGS5, pp9484 |
| Gene |
UniProtKB-ID:
INF2_HUMAN
UniprotKB:
Q27J81
UniParc:
UPI00000709E0,
UPI000156D0FA,
UPI000156D0FB
EMBL:
AK025709,
CH471061,
AK290083,
BC064828,
BC006173,
AL832905,
DQ395340,
BC008756,
BX248757,
AL583722,
DQ395339,
DQ395338
Ensembl:
ENSG00000203485
KO:
hsa:64423
|
| Nucleutide sequences |
EMBL-CDS:
AAH64828.1,
CAD66564.1,
AAH06173.1,
ABD59344.1,
CAH10628.1,
BAB15224.1,
BAF82772.1,
AAH08756.2,
ABD59345.1,
EAW81872.1,
ABD59343.1
Ensembl_TRS:
ENST00000330634,
ENST00000398337,
ENST00000392634
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000376410,
ENSP00000381380,
ENSP00000376406
RefSeq:
NP_116103.1,
NP_071934.3,
NP_001026884.3
|
| Others |
UniRef100:
UniRef100_Q27J81
UniRef90:
UniRef90_Q27J81
UniRef50:
UniRef50_Q27J81
UniGene:
Hs.24956
CCDS:
CCDS41999.1,
CCDS9989.2,
CCDS45173.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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