| Type | Description |
|---|---|
| Definition | uroporphyrinogen decarboxylase |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 10:50:00 | These results expand the molecular heterogeneity of Porphyria Cutanea Tarda and Hepatoerythropoietic Porphyria by adding a total of 19 novel UROD mutations. | 30514647 |
| 2016-10-22 10:27:00 | a new mutation in the UROD gene in Egyptian patients with Hepatoerythropoietic porphyria, is reported. | 26789143 |
| 2015-07-04 11:42:00 | a new insight in the conformational changes occurred in the mutant structures of UROD protein. | 24777812 |
| 2014-06-14 10:22:00 | Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer. | 23140436 |
| 2013-12-28 11:04:00 | Expression of the D306Y mutation results in an insoluble recombinant protein. G318R and K297N have little effect on the structure or activity of recombinant URO-D, but the proteins display reduced stability in vitro. | 19656450 |
| Type | IDs |
|---|---|
| Synonymous | PCT, UPD |
| Gene |
UniProtKB-ID:
DCUP_HUMAN
UniprotKB:
P06132
UniParc:
UPI0000112E85
EMBL:
AF104426,
AF104425,
AL359473,
AF104434,
AF104438,
X89267,
AK291877,
CH471059,
M14016,
AF104436,
AY292986,
CR542057,
AF104428,
AF104433,
AF104421,
BC001778,
AF104439,
AF104432,
AF104435,
AF104424,
AF104437,
AF104429,
AF104430,
AF104422,
AF104427,
AF047383,
AF104431,
AF104423,
AF104440,
CR456976,
U30787,
BT006737,
M60891
Ensembl:
ENSG00000126088
KO:
hsa:7389
|
| Nucleutide sequences |
EMBL-CDS:
AAB59456.1,
AAC03563.1,
AAD04576.1,
AAD04590.1,
AAD04582.1,
AAD04579.1,
AAD04571.1,
AAD04583.1,
AAD04574.1,
CAG46854.1,
AAD04577.1,
AAD04587.1,
BAF84566.1,
AAD04581.1,
AAD04585.1,
AAH01778.1,
AAD04575.1,
CAA61540.1,
EAX07007.1,
CAG33257.1,
AAD04588.1,
AAD04589.1,
AAD04580.1,
AAD04572.1,
AAD04584.1,
AAP35383.1,
AAP44118.1,
AAD04586.1,
AAD04573.1,
AAD04578.1,
AAC50482.1,
AAA61258.1
Ensembl_TRS:
ENST00000246337
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000246337
RefSeq:
NP_000365.3
|
| Others |
UniRef100:
UniRef100_P06132
UniRef90:
UniRef90_P06132
UniRef50:
UniRef50_P06132
UniGene:
Hs.78601
CCDS:
CCDS518.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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