| Type | Description |
|---|---|
| Definition | schlafen family member 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:53:00 | Human Schlafen 5 regulates reversible epithelial and mesenchymal transitions in breast cancer by suppression of ZEB1 transcription. | 32488136 |
| 2020-08-12 13:30:00 | This is the first study to report that SLFN5 inhibits cancer migration and invasiveness in several common cancer cell lines by repressing MT1-MMP expression via the AKT/GSK-3beta/beta-catenin signalling pathway, suggesting that SLFN5 plays wide inhibitory roles in various cancers. | 30844429 |
| 2020-03-07 11:39:00 | Study results demonstrated that overexpression of SLFN5 promoted the morphology transformation of lung cancer cell line A549 from epithelial to mesenchymal, as well as migration and invasion. However, knockdown of SLFN5 resulted in the opposite results. Results suggest that SLFN5 may act as a synergist in lung cancer cell tumorigenesis and progression through beta-catenin/Snail/E-cadherin pathway. | 31472120 |
| 2017-11-04 10:49:00 | Type-I IFN treatment triggers the interaction of with SLFN5, and the resulting complex negatively controls gene transcription via interferon stimulated response elements | 28671669 |
| 2017-09-23 12:55:00 | In this study population, elevated SLFN5 protein expression in patients with intestinal metaplasia correlated with progression to gastric cancer | 27032393 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SLFN5_HUMAN,
B4E128_HUMAN
UniprotKB:
Q08AF3,
B4E128
UniParc:
UPI0000237686,
UPI000006F450,
UPI00017A8482
EMBL:
AK303632,
BC021238,
AC022706,
BC125201,
AK054668,
AC022916,
BC125200
Ensembl:
ENSG00000166750
KO:
hsa:162394
|
| Nucleutide sequences |
EMBL-CDS:
BAB70788.1,
AAH21238.1,
AAI25201.1,
AAI25202.1,
BAG64640.1
Ensembl_TRS:
ENST00000299977,
ENST00000592325,
ENST00000542451
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000299977,
ENSP00000466984,
ENSP00000440537
RefSeq:
NP_659412.3,
NP_001317112.1
|
| Others |
UniRef100:
UniRef100_B4E128,
UniRef100_Q08AF3
UniRef90:
UniRef90_Q08AF3,
UniRef90_A0A2I3N1U4
UniRef50:
UniRef50_Q08AF3-2,
UniRef50_Q08AF3
UniGene:
Hs.709347
CCDS:
CCDS32619.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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