| Type | Description |
|---|---|
| Definition | ubiquitin protein ligase E3 component n-recognin 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:31:00 | UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD. | 32558906 |
| 2019-12-07 11:28:00 | The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes. | 30111582 |
| 2019-07-20 10:06:00 | Pathogenic mutation in UBR4 gene is associated with Episodic Ataxia. | 29062094 |
| 2017-01-28 10:22:00 | Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from podocytes. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex. | 26792178 |
| 2015-12-05 11:07:00 | Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. | 25582440 |
| Type | IDs |
|---|---|
| Synonymous | RBAF600, ZUBR1, p600 |
| Gene |
UniProtKB-ID:
UBR4_HUMAN
UniprotKB:
Q5T4S7
UniParc:
UPI000150AF35,
UPI000150AF34,
UPI000006E63B,
UPI000150AF3B,
UPI000150AF36,
UPI000021276F
EMBL:
AL049972,
AK022322,
BC073905,
AL357564,
AF055010,
AF348492,
AJ505016,
AB007931,
BC018694,
AL137127,
BC063573,
BC096758,
AB037728
Ensembl:
ENSG00000127481
KO:
hsa:23352
|
| Nucleutide sequences |
EMBL-CDS:
BAA32307.1,
AAH63573.1,
AAH73905.1,
CAB43227.1,
BAA92545.1,
AAC09360.1,
BAB14011.1,
AAL83880.1,
CAD43719.1,
AAH18694.2,
AAH96758.1
Ensembl_TRS:
ENST00000375254,
ENST00000375218
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364366,
ENSP00000364403
RefSeq:
XP_016856315.2,
XP_011539421.2,
XP_016856311.2,
XP_011539410.2,
XP_011539417.2,
XP_011539420.2,
XP_016856316.2,
XP_011539414.2,
XP_016856314.2,
XP_016856319.2,
XP_011539423.2,
XP_011539418.2,
XP_016856312.2,
XP_016856313.2,
NP_065816.2,
XP_016856317.2,
XP_011539422.2,
XP_011539416.2,
XP_011539411.2,
XP_011539412.2,
XP_011539419.2,
XP_011539415.2,
XP_016856318.2,
XP_011539413.2
|
| Others |
UniRef100:
UniRef100_Q5T4S7
UniRef90:
UniRef90_Q5T4S7
UniRef50:
UniRef50_Q5T4S7
UniGene:
Hs.148078,
Hs.649405
CCDS:
CCDS189.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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