| Type | Description |
|---|---|
| Definition | Aly/REF export factor |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:14:00 | An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. | 33767157 |
| 2020-01-25 10:11:00 | We demonstrate that eIF4A3 stimulates Alyref deposition not only on spliced RNAs close to exon junction complex sites but also on single-exon transcripts | 31104896 |
| 2019-11-02 12:01:00 | In both ORF57 and ICP27 the interaction sites for ALYREF and UIF partially overlap, suggestive of mutually exclusive binding. The data provide a map of the binding sites responsible for promoting herpes virus mRNA export, enabling future studies to accurately probe these interactions and reveal the functional consequences for UIF and ALYREF redundancy | 30301920 |
| 2018-01-20 11:10:00 | Dysregulation of ALYREF-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2. | 28418038 |
| 2017-10-28 11:24:00 | ALYREF mainly binds to the 5' and the 3' regions of the mRNA. ALYREF is likely recruited to mRNAs by PABPN1 and the 3' processing machinery. | 28934468 |
| Type | IDs |
|---|---|
| Synonymous | ALY, ALY/REF, BEF, REF, THOC4 |
| Gene |
UniProtKB-ID:
THOC4_HUMAN,
E9PB61_HUMAN
UniprotKB:
Q86V81,
E9PB61
UniParc:
UPI00001AFE08,
UPI00001969CC
EMBL:
AF047002,
AC145207,
BC052302
Ensembl:
ENSG00000183684
KO:
hsa:10189
|
| Nucleutide sequences |
EMBL-CDS:
AAH52302.1,
AAD09608.1
Ensembl_TRS:
ENST00000331204,
ENST00000505490
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000331817,
ENSP00000421592
RefSeq:
NP_005773.3
|
| Others |
UniRef100:
UniRef100_Q86V81
UniRef90:
UniRef90_Q86V81
UniRef50:
UniRef50_Q86V81
UniGene:
Hs.534385
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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