| Type | Description |
|---|---|
| Definition | methionine adenosyltransferase 2B |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 10:45:00 | the protein-protein interacting surface formed in MATa2:MATbeta complexes is explored to demonstrate that several quinolone-based compounds modulate the activity of MATa2 and its mutants, providing a rational for chemical design/intervention responsive to the level of S-Adenosylmethionine in the cellular environment | 30776190 |
| 2020-03-14 10:46:00 | Results found that MAT2B was overexpressed in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis for HCC patients. Its silencing could suppress liver cancer cell migration and invasion through the inhibition of EGFR signaling, which suggested that MAT2B might serve as a new prognostic marker for HCC. | 31493275 |
| 2019-08-31 10:17:00 | MAT2B was markedly increased in osteosarcoma (OS) specimens compared with the normal bone tissues, and it was additionally abundantly expressed in OS cell lines. Inhibition of MAT2B expression caused a marked decrease in proliferation and significant increase in apoptosis. Results demonstrated that MAT2B functions as a tumor oncogene in OS in vivo and in vitro via regulation of EGFR and PCNA. | 30942439 |
| 2019-04-06 12:00:00 | This study showed that variant upstream of MAT2B whose association is prominent in back, hip, knee, and neck pain-provides preliminary evidence of shared contributing mechanisms at the genetic-molecular level. | 29240606 |
| 2017-04-08 10:54:00 | Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity. | 27573889 |
| Type | IDs |
|---|---|
| Synonymous | MAT-II, MATIIbeta, Nbla02999, SDR23E1, TGR |
| Gene |
UniProtKB-ID:
MAT2B_HUMAN,
A0A140VJP2_HUMAN
UniprotKB:
Q9NZL9,
A0A140VJP2
UniParc:
UPI000004BA67,
UPI00006E2511,
UPI00006CA0C9,
UPI0000037B81,
UPI0000422FA6
EMBL:
AL136664,
AF182814,
AY358695,
AJ243721,
BC093030,
CH471062,
BC005218,
AB073390,
DQ395260,
DQ413183,
AF113225,
BC066645,
HM005431,
AK312365
Ensembl:
ENSG00000038274
KO:
hsa:27430
|
| Nucleutide sequences |
EMBL-CDS:
CAB56837.1,
AAG39296.1,
ABD59011.1,
AAF28477.1,
EAW61517.1,
CAB66599.1,
AAH05218.1,
ABD85290.1,
BAE45720.1,
AAH93030.1,
AAQ89058.1,
AAH66645.1,
BAG35283.1,
AEE61029.1
Gene_ORFName:
Nbla02999,
UNQ2435/PRO4995,
MSTP045
Ensembl_TRS:
ENST00000321757,
ENST00000518095,
ENST00000280969
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000428046,
ENSP00000280969,
ENSP00000325425
RefSeq:
NP_037415.1,
NP_877725.1
|
| Others |
UniRef100:
UniRef100_Q9NZL9
UniRef90:
UniRef90_Q9NZL9
UniRef50:
UniRef50_Q9NZL9
UniGene:
Hs.54642
CCDS:
CCDS4365.1,
CCDS4364.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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