| Type | Description |
|---|---|
| Definition | ubiquitin associated protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-26 11:11:00 | mRNA in the fibroblasts of individuals with pathological truncating variants in UBAP1 escapes nonsense-mediated decay and thus leads to the expression of truncated proteins. In addition, concentrations of the full-length protein are reduced in comparison to those in controls. This suggests either a dominant-negative effect or haploinsufficiency. | 30929741 |
| 2020-05-30 12:15:00 | Our study provides genetic and biochemical evidence that mutations in UBAP1 can cause pure autosomal dominant spastic paraplegia. | 31203368 |
| 2020-02-08 11:51:00 | UBAP1 links endosomal trafficking to the ubiquitination machinery pathways that have been previously implicated in Hereditary Spastic Paraplegia | 30929741 |
| 2020-02-08 10:59:00 | The full-length UBAP1 protein is involved in endosomal dynamics in neurons, while loss of UBAP1 function may perturb endosomal fusion and sorting of ubiquitinated cargos. These effects could be more prominent in neurons, thereby giving rise to the phenotype of a neurodegenerative disease such as hereditary spastic paraplegia. | 31515522 |
| 2017-07-15 12:19:00 | Combined targeting of UBAP1 and toll-like receptor adaptors TIRAP and MyD88 by Pseudomonas aeruginosa PumA impedes both cytokine and toll-like receptor signalling, highlighting a novel strategy for innate immune evasion. | 28483816 |
| Type | IDs |
|---|---|
| Synonymous | NAG20, UAP, UBAP, UBAP-1 |
| Gene |
UniProtKB-ID:
UBAP1_HUMAN,
A0A6G6AA68_HUMAN
UniprotKB:
Q9NZ09,
A0A6G6AA68
UniParc:
UPI000046FE8B,
UPI0001C2BF9D,
UPI0000073E7F,
UPI0001C2BF9E
EMBL:
MN137233,
BC098316,
AL136733,
BC100668,
BC098141,
AK223235,
CR533551,
MN137232,
AK074969,
MN137235,
MN137231,
CH471071,
AK303711,
AK295482,
BC020950,
AF222043,
MN137236,
AK074745,
AK074812,
AL353662,
BC099726,
MN137234,
AK074995,
AK074724
Ensembl:
ENSG00000165006
KO:
hsa:51271
|
| Nucleutide sequences |
EMBL-CDS:
AAI00669.1,
CAB66667.1,
BAC11342.1,
BAC11224.1,
EAW58468.1,
BAC11162.1,
BAH12084.1,
BAC11176.1,
AAH98316.1,
EAW58470.1,
EAW58467.1,
BAC11323.1,
AAH99726.1,
EAW58469.1,
AAH20950.1,
BAH14025.1,
CAG38582.1,
AAH98141.1,
AAF37827.2,
BAD96955.1,
QID05733.1,
QID05731.1,
QID05734.1,
QID05730.1,
QID05735.1,
QID05732.1
Gene_ORFName:
NAG20
Ensembl_TRS:
ENST00000625521,
ENST00000379186,
ENST00000359544,
ENST00000297661
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000486574,
ENSP00000352541,
ENSP00000297661,
ENSP00000368484
RefSeq:
NP_001164672.1,
XP_016870290.1,
NP_001164675.1,
XP_011516202.1,
XP_011516200.1,
NP_001164673.1,
NP_001164674.1,
NP_057609.2,
XP_011516201.1,
XP_016870291.1,
XP_006716842.1
|
| Others |
UniRef100:
UniRef100_Q9NZ09
UniRef90:
UniRef90_Q9NZ09
UniRef50:
UniRef50_Q9NZ09
UniGene:
Hs.268963
CCDS:
CCDS55303.1,
CCDS6550.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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