| Type | Description |
|---|---|
| Definition | bromodomain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:58:00 | Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system. | 31792058 |
| 2020-06-27 10:11:00 | BRD3 is recruited to and controls the activity of a subset ERa transcriptional enhancers, providing a therapeutic opportunity to target BRD3 with BET inhibitors in ERa-positive breast cancers. | 31551256 |
| 2020-04-04 12:35:00 | This study presents the first co-crystal structure of SPOP and a bromodomain containing protein (BRD3). | 31026449 |
| 2019-11-16 11:51:00 | The BET proteins Brd3 and Brd4 were shown to bind to the NOX4 promoter and drive TGF-beta-induced NOX4 expression. Our data indicate a critical role of BET proteins in promoting redox imbalance and pulmonary myofibroblast activation and support BET bromodomain inhibitors as a potential therapy for fibrotic lung disease. | 31119153 |
| 2019-08-03 12:26:00 | Results provide evidence that both BRD3 and BRD4 are repressors of epithelial-to-mesenchymal transition in breast cancer cells. | 29437854 |
| Type | IDs |
|---|---|
| Synonymous | ORFX, RING3L |
| Gene |
UniProtKB-ID:
BRD3_HUMAN,
A0A024R8H6_HUMAN,
B4DS09_HUMAN
UniprotKB:
Q15059,
A0A024R8H6,
B4DS09
UniParc:
UPI000006F0F4,
UPI00017A7BB0,
UPI0000126ACD
EMBL:
AY513270,
D26362,
AL445931,
BC032124,
Z81330,
AK299519,
CH471090
Ensembl:
ENSG00000169925
KO:
hsa:8019
|
| Nucleutide sequences |
EMBL-CDS:
BAA05393.2,
AAH32124.1,
EAW88114.1,
EAW88113.1,
AAS82952.1,
EAW88115.1,
BAG61471.1
Gene_ORFName:
hCG_30083
Ensembl_TRS:
ENST00000303407,
ENST00000371834
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000360900,
ENSP00000305918
RefSeq:
XP_011517354.1,
XP_016870655.1,
XP_006717354.1,
NP_031397.1,
XP_016870654.1
|
| Others |
UniRef100:
UniRef100_Q15059
UniRef90:
UniRef90_Q15059
UniRef50:
UniRef50_Q15059
UniGene:
Hs.522472,
Hs.654869
CCDS:
CCDS6980.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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