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10393 ANAPC10

10393

ANAPC10

anaphase promoting complex subunit 10

protein-coding

Homo sapiens

基因描述

Type Description
Definition anaphase promoting complex subunit 10

研究结论

Date Results Publications
2020-05-30 11:31:00 APC10 was overexpressed in non-small cell lung cancer cell lines compared to human bronchial epithelial cell lines. APC10 was shown to interact with GAC; knocking down APC10 downregulated glutamine metabolism to induce autophagy, resulting in effective inhibition of the proliferation and migration of non-small cell lung cancer cells. 31023143
2011-04-30 10:23:00 Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A 21336306
2011-02-26 11:36:00 Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 and Doc1. 21186364

名称对应

Type IDs
Synonymous APC10, DOC1
Gene
UniProtKB-ID: APC10_HUMAN
UniprotKB: Q9UM13
UniParc: UPI00000467AB
EMBL: CH471056, DQ304649, AF132794, BC005217, AL080090, AB012109
Ensembl: ENSG00000164162
KO: hsa:10393
Nucleutide sequences
EMBL-CDS: EAX05050.1, AAD30527.1, BAA86953.1, CAB45705.1, ABB96248.1, AAH05217.1, EAX05051.1
Ensembl_TRS: ENST00000613466, ENST00000309439, ENST00000507656, ENST00000451299
Protein sequencees
Ensembl_PRO: ENSP00000423995, ENSP00000478501, ENSP00000310071, ENSP00000403891
RefSeq: NP_001305296.1, XP_016863128.1, XP_011529833.1, NP_001243637.1, XP_011529826.1, XP_011529831.1, XP_011529827.1, NP_001243639.1, XP_024309643.1, XP_011529834.1, XP_011529829.1, XP_016863129.1, XP_016863130.1, NP_001243641.1, NP_001243635.1, NP_055700.2, XP_016863131.1, NP_001243636.1, NP_001243640.1, NP_001243638.1, XP_016863133.1
Others
UniRef100: UniRef100_Q9UM13
UniRef90: UniRef90_Q9UM13
UniRef50: UniRef50_Q9UM13
UniGene: Hs.480876
CCDS: CCDS43273.1

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