| Type | Description |
|---|---|
| Definition | 5'-3' exoribonuclease 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:13:00 | XRN2, a gene proximal to an autism spectrum disorder (ASD) genome-wide association study (GWAS) locus, was inferred to be significantly upregulated in ASD, providing insight into the functional consequence of this associated locus. | 31230729 |
| 2020-06-06 13:34:00 | Authors engineered cells in which the 3'-->5' exoribonucleases of the exosome complex, DIS3 and EXOSC10, can be rapidly eliminated to assess their immediate roles in nuclear RNA biology. The 5'-->3' exoribonuclease, XRN2, has little activity on exosome substrates, but its elimination uncovers different mechanisms for the early termination of transcription from protein-coding gene promoters. | 30840897 |
| 2018-12-22 11:34:00 | Xrn2 depletion induces a transcriptional termination defect at the majority of protein-coding genes. | 30035655 |
| 2017-09-23 11:38:00 | depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. | 28115624 |
| 2017-09-23 10:50:00 | XRN2 is a novel regulator of EMT that contributes to the metastatic processes in lung cancer through a novel miRNA regulatory mechanism. | 28319071 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
XRN2_HUMAN,
B4DZC3_HUMAN
UniprotKB:
Q9H0D6,
B4DZC3
UniParc:
UPI0000037D02,
UPI0000DE1FAF,
UPI00017A8590
EMBL:
AF064257,
AF152169,
AK302846,
AL117332,
BC006417,
AY382900,
AL136841,
AL158013,
AK000084
Ensembl:
ENSG00000088930
KO:
hsa:22803
|
| Nucleutide sequences |
EMBL-CDS:
AAD55138.1,
CAB66775.1,
AAQ13577.1,
AAR24369.1,
AAH06417.2,
BAA90934.1,
BAG64035.1
Ensembl_TRS:
ENST00000377191
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000366396
RefSeq:
NP_001304889.1,
NP_036387.2,
XP_016883212.1,
XP_016883211.1,
XP_016883213.1
|
| Others |
UniRef100:
UniRef100_B4DZC3,
UniRef100_Q9H0D6
UniRef90:
UniRef90_B4DZC3,
UniRef90_Q9H0D6
UniRef50:
UniRef50_Q5ZIP4,
UniRef50_Q9H0D6
UniGene:
Hs.255932
CCDS:
CCDS13144.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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