| Type | Description |
|---|---|
| Definition | aspartyl-tRNA synthetase |
| Date | Results | Publications |
|---|---|---|
| 2019-03-09 12:37:00 | This study demonstrates that human mitochondrial AspRS, ArgRS, and LysRS, each have a specific sub-mitochondrial distribution, with ArgRS being exclusively localized in the membrane, LysRS exclusively in the soluble fraction, and AspRS being present in both. | 30006346 |
| 2017-06-24 10:27:00 | Genetic variants of the DARS gene may influence individual susceptibility to isolated VSD in Chinese Han population. Risk of VSD was significantly associated with rs2164331 [G/A; odds ratio (OR) = 0.78, 95% confidence interval (CI) = 0.69-0.91; P = 3.17 x 10(-3)], rs6738266 [G/A; OR = 1.17, 95% CI = 1.05-1.29, P = 1.83 x 10(-3)], and rs309143 [G/A; OR = 1.09, 95% CI = 1.01-1.17; P = 3.12 x 10(-2)]. | 27871331 |
| 2014-03-22 10:37:00 | Report on the crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) at a resolution of 2.25 A. | 23609930 |
| 2013-07-06 10:02:00 | Mutations in DARS cause hypomyelination with brain stem and spinal cord involvement and leg spasticity. | 23643384 |
| 2010-01-21 00:00:00 | the N-terminus shows a less-ordered structure with flexible beta-turn, suggesting that when tRNA is stretched, the dissociation rate of Asp-tRNA from aspartyl-tRNA synthetase is reduced, giving time for elongation factor 1alpha to interact with Asp-tRNA. | 12824064 |
| Type | IDs |
|---|---|
| Synonymous | HBSL, aspRS |
| Gene |
UniProtKB-ID:
SYDC_HUMAN,
A0A140VJW5_HUMAN
UniprotKB:
P14868,
A0A140VJW5
UniParc:
UPI000013639B,
UPI0000425C59
EMBL:
BT006710,
AY762100,
BC000629,
J05032,
AC093391,
AC011999,
CH471058,
CR749809,
AK290607,
BC107749,
HM005505,
AK222476
Ensembl:
ENSG00000115866
KO:
hsa:1615
|
| Nucleutide sequences |
EMBL-CDS:
BAD96196.1,
EAX11620.1,
AAX07827.1,
AAA35567.1,
BAF83296.1,
AAP35356.1,
CAH18669.1,
EAX11617.1,
AAH00629.1,
AAI07750.1,
AEE61102.1
Gene_ORFName:
PIG40
Ensembl_TRS:
ENST00000264161
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264161
RefSeq:
NP_001280241.1,
NP_001340.2
|
| Others |
UniRef100:
UniRef100_P14868
UniRef90:
UniRef90_P14868
UniRef50:
UniRef50_P14868
UniGene:
Hs.503787
CCDS:
CCDS2180.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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