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23085 ERC1

23085

ERC1

ELKS/RAB6-interacting/CAST family member 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition ELKS/RAB6-interacting/CAST family member 1

研究结论

Date Results Publications
2020-06-27 11:33:00 The ELKS forms a potent insulin secretion complex with L-type voltage-dependent Ca(2+) channels on the vascular-facing plasma membrane of beta-cells, enabling polarized Ca(2+) influx and first-phase insulin secretion from islets. 31500835
2019-03-16 11:09:00 Several studies had established that ELKS is a redundant scaffold at the active zone, and that disruption of this scaffold impairs fusion of synaptic vesicles. In non-neuronal cells, scaffolding and exocytotic functions of ELKS seem to be important for constitutive secretion of other cargo. [review] 29491150
2019-01-26 10:59:00 Knockdown of ERC1, RAB4B, COPA, and COPB2, caused profound loss of virus production. 29946045
2018-11-24 12:06:00 The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. 29348417
2017-11-11 10:07:00 ELKS removal has differential, synapse-specific effects on readily releasable vesicles and probability of release, and findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming. 27253063

名称对应

Type IDs
Synonymous Cast2, ELKS, ERC-1, RAB6IP2
Gene
UniProtKB-ID: RB6I2_HUMAN, G8JLD3_HUMAN, X6RLX0_HUMAN
UniprotKB: Q8IUD2, G8JLD3, X6RLX0
UniParc: UPI000007479B, UPI0002841219, UPI0000074799, UPI000007365C, UPI000204AA5F, UPI000007479A, UPI000007479C
EMBL: BC068006, AC092469, KC877502, AB053470, AB029004, AC004803, AC004672, AC004802, BC150248, AC004671, AB015617, AC006561, BC132784, KF455581, BC132782, AK000148, AB053468, AK092201, AB053471, AB053469, CH471116, AC004804
Ensembl: ENSG00000082805
KO: hsa:23085
Nucleutide sequences
EMBL-CDS: BAA83033.2, EAW88934.1, AAI50249.1, BAA88763.1, AAH68006.1, AAI32785.1, EAW88938.1, BAC03827.1, BAC54107.1, BAA90975.1, BAC54110.1, BAC54108.1, AAI32783.1, BAC54109.1, EAW88932.1, EAW88936.1
Ensembl_TRS: ENST00000347735, ENST00000397203, ENST00000440394, ENST00000589028, ENST00000543086, ENST00000545948, ENST00000611180, ENST00000360905, ENST00000355446, ENST00000546231
Protein sequencees
Ensembl_PRO: ENSP00000380386, ENSP00000354158, ENSP00000438546, ENSP00000479523, ENSP00000468263, ENSP00000340054, ENSP00000442976, ENSP00000410064, ENSP00000347621, ENSP00000442739
RefSeq: XP_016874562.1, XP_016874546.1, XP_016874548.1, XP_016874551.1, XP_016874561.1, XP_016874559.1, XP_016874564.1, XP_011519243.1, XP_016874544.1, XP_016874558.1, XP_016874542.1, XP_016874541.1, XP_016874560.1, XP_016874545.1, XP_016874543.1, XP_016874554.1, XP_016874563.1, XP_016874552.1, XP_016874550.1, XP_016874556.1, NP_829883.1, NP_001288177.1, XP_016874553.1, XP_016874555.1, XP_016874547.1, XP_016874557.1, NP_829884.1, XP_016874549.1
Others
UniRef100: UniRef100_Q8IUD2, UniRef100_X6RLX0, UniRef100_G8JLD3
UniRef90: UniRef90_Q8IUD2
UniRef50: UniRef50_Q8IUD2
UniGene: Hs.601216
CCDS: CCDS8508.1, CCDS53732.1

全选

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