| Type | Description |
|---|---|
| Definition | chromatin assembly factor 1 subunit B |
| Date | Results | Publications |
|---|---|---|
| 2019-06-29 12:08:00 | Study revealed that CHAF1B was highly expressed in nonsmall cell lung cancer (NSCLC) lung tissues and 95D cells. Survival analysis indicated that high CHAF1B expression in tumor tissue was associated with poor clinical outcomes in NSCLC patients. CHAF1B knockdown in 95D cells markedly inhibited tumor proliferation, reduced colony formation, induced cell cycle arrest and promoted apoptosis. | 30720130 |
| 2018-09-29 11:16:00 | The volumes of the tumors were similar between those injected with the empty vector and control, but were significantly smaller in the knockdown models, suggesting that the knockdown of the CHAF1B gene inhibited tumor growth. H&E staining revealed that tumors were developed in mice in all groups. | 29767268 |
| 2015-10-24 11:06:00 | All the evaluated malignant tumors showed CAF-1 p60 overexpression, confirming the emerging role of CAF-1 p60 as a new proliferation and prognostic marker for cancer. | 23109837 |
| 2014-06-14 11:57:00 | The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11). | 24039914 |
| 2011-04-09 10:58:00 | Overexpression of CAF-1/p60, on histological and/or cytological samples, characterizes malignant salivary gland tumours with aggressive behaviour | 21109952 |
| Type | IDs |
|---|---|
| Synonymous | CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7 |
| Gene |
UniProtKB-ID:
CAF1B_HUMAN
UniprotKB:
Q13112
UniParc:
UPI0000126DD1
EMBL:
AP001725,
U20980,
AP000694,
X98262,
BC021218
Ensembl:
ENSG00000159259
KO:
hsa:8208
|
| Nucleutide sequences |
EMBL-CDS:
BAA95549.1,
BAA89426.1,
CAA66915.1,
AAA76737.1,
AAH21218.1
Ensembl_TRS:
ENST00000314103
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000315700
RefSeq:
NP_005432.1,
XP_011528057.1,
XP_016883967.1,
XP_016883966.1
|
| Others |
UniRef100:
UniRef100_Q13112
UniRef90:
UniRef90_Q13112
UniRef50:
UniRef50_Q13112
UniGene:
Hs.75238
CCDS:
CCDS13644.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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