| Type | Description |
|---|---|
| Definition | LEO1 homolog, Paf1/RNA polymerase II complex component |
| Date | Results | Publications |
|---|---|---|
| 2019-03-02 10:12:00 | Here, we identified Leo1 as a direct and specific substrate of PRL-3. Serine-dephosphorylated form of Leo1 binds directly to beta-catenin, promoting the nuclear accumulation of beta-catenin and transactivation of TCF/LEF downstream target genes such as cyclin D1 and c-myc | 30305722 |
| 2014-08-30 11:19:00 | PRL-3 and Leo1 levels were positively associated in AML patient samples. | 24686170 |
| 2014-02-15 12:31:00 | The results show that the Paf1/Leo1 heterodimer is necessary for its binding to histone H3, the histone octamer, and nucleosome in vitro. | 24038468 |
| 2010-07-12 12:17:00 | Screened glioblastomas and oligodendrogliomas for fusion genes by identifying aberrant 5'-3' expression of genes that lie over regions of a copy number change. A fusion gene between exon 11 of LEO1 and exon 10 of SLC12A1 was identified. | 20196086 |
| Type | IDs |
|---|---|
| Synonymous | RDL |
| Gene |
UniProtKB-ID:
LEO1_HUMAN
UniprotKB:
Q8WVC0
UniParc:
UPI00001FE4D2,
UPI0000071CA0
EMBL:
AK055762,
BC018147,
AY302186
Ensembl:
ENSG00000166477
KO:
hsa:123169
|
| Nucleutide sequences |
EMBL-CDS:
AAP68819.1,
AAH18147.1,
BAB71006.1
Ensembl_TRS:
ENST00000315141,
ENST00000299601
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000299601,
ENSP00000314610
RefSeq:
NP_620147.1,
NP_001273359.1,
NP_001310833.1,
NP_001310832.1,
XP_016877400.1
|
| Others |
UniRef100:
UniRef100_Q8WVC0
UniRef90:
UniRef90_Q8WVC0
UniRef50:
UniRef50_Q8WVC0
UniGene:
Hs.567662
CCDS:
CCDS10146.1,
CCDS66767.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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