| Type | Description |
|---|---|
| Definition | UPF3B regulator of nonsense mediated mRNA decay |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 10:50:00 | RNAseq studies reveal that depletion of ICE1 globally enhances accumulation and stability of NMD-target mRNAs. Further, our data suggest that ICE1 uses a putative MIF4G domain to interact with exon junction complex (EJC) proteins and promotes the association of the NMD protein UPF3B with the EJC. | 29528287 |
| 2017-10-21 12:24:00 | The authors discovered that UPF3B (i) interacts with the release factors, (ii) delays translation termination and (iii) dissociates post-termination ribosomal complexes that are devoid of the nascent peptide. | 28899899 |
| 2016-10-22 11:57:00 | UPF3B gene mutation is associated with Lujan-Fryns syndrome. | 26358559 |
| 2016-01-23 11:02:00 | the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of nonsense-mediated mRNA decay pathway function altering neuronal differentiation. | 26012578 |
| 2014-01-25 11:10:00 | These findings indicate that SATB2 activates UPF3B expression through binding to its promoter. | 23925499 |
| Type | IDs |
|---|---|
| Synonymous | HUPF3B, MRX62, MRXS14, RENT3B, UPF3BP1, UPF3BP2, UPF3BP3, UPF3X, Upf3p-X |
| Gene |
UniProtKB-ID:
REN3B_HUMAN
UniprotKB:
Q9BZI7
UniParc:
UPI000006FF6A,
UPI000006D21C
EMBL:
AF318576,
CH471161,
AY013251,
BC121017
Ensembl:
ENSG00000125351
KO:
hsa:65109
|
| Nucleutide sequences |
EMBL-CDS:
EAW89845.1,
AAI21018.1,
AAG48511.1,
EAW89842.1,
EAW89844.1,
EAW89846.1,
AAG60691.1
Ensembl_TRS:
ENST00000345865,
ENST00000276201
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000245418,
ENSP00000276201
RefSeq:
NP_075386.1,
XP_016885226.1,
XP_016885229.1,
XP_016885227.1,
XP_016885228.1,
NP_542199.1
|
| Others |
UniRef100:
UniRef100_Q9BZI7
UniRef90:
UniRef90_Q9BZI7
UniRef50:
UniRef50_Q9BZI7
UniGene:
Hs.103832
CCDS:
CCDS14588.1,
CCDS14587.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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