| Type | Description |
|---|---|
| Definition | inosine triphosphatase |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:58:00 | We evaluated the role of inosine triphosphatase (ITPA) in 6-mercaptopurine (6-MP) sensitivity during treatment of pediatric patients with acute lymphoblastic leukemia | 31635813 |
| 2020-03-14 12:44:00 | ITPA genotype and erythrocyte RTP concentrations were major factors associated with reduced Hb levels in RBV therapy for CHC. | 30817703 |
| 2020-02-15 10:10:00 | TPMT *3C and TPMT*12 are the key determinants of 6-mercaptopurine-mediated hematological toxicity in acute lymphoblastic leukemia, while other variants of TPMT (int3, int4 and int7) and ITPA ex2 interact synergistically with TPMT*3C or TPMT*12 variant alleles to enhance the toxicity | 30806759 |
| 2019-09-21 10:23:00 | Genetic analysis of 85 unrelated "mutation negative" probands with Martsolf or Martsolf-like syndromes identified two individuals with different homozygous null mutations in ITPA, the gene encoding inosine triphosphate pyrophosphatase (ITPase). Both probands were from multiplex families with a consistent, lethal and highly distinctive disorder; a Martsolf-like syndrome with infantile-onset dilated cardiomyopathy. | 30856165 |
| 2019-03-30 11:57:00 | Thiopurine methyltransferase (TPMT) and inosine triphosphatase (ITPA) genotypes significantly influence the metabolism of 6-mercaptopurine (6MP). | 29387964 |
| Type | IDs |
|---|---|
| Synonymous | C20orf37, HLC14-06-P, ITPase, My049, NTPase, dJ794I6.3 |
| Gene |
UniProtKB-ID:
ITPA_HUMAN,
Q8WWI0_HUMAN,
A0A0S2Z3W7_HUMAN,
A0A0S2Z423_HUMAN
UniprotKB:
Q9BY32,
Q8WWI0,
A0A0S2Z3W7,
A0A0S2Z423
UniParc:
UPI0000072BC2,
UPI00001A95E9,
UPI000020691D,
UPI0000073B25
EMBL:
AF219116,
EF199841,
AF334680,
BI115811,
AL109976,
AF063607,
GQ891343,
CH471133,
AF026816,
AL121891,
KU178148,
AB062127,
BC010138,
EF213026,
KU178149
Ensembl:
ENSG00000125877
KO:
hsa:3704
|
| Nucleutide sequences |
EMBL-CDS:
AAB82608.2,
ABP01354.1,
EAX10541.1,
ABO70316.1,
AAH10138.1,
BAB93459.1,
AAG43165.1,
AAK21848.1,
AAL57168.1,
EAX10542.1,
ALQ33606.1,
ADO22205.1,
ALQ33607.1
Gene_ORFName:
My049,
OK/SW-cl.9,
hCG_39262
Ensembl_TRS:
ENST00000455664,
ENST00000399838,
ENST00000380113
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000369456,
ENSP00000382732,
ENSP00000413282
RefSeq:
NP_258412.1,
NP_001254552.1,
NP_852470.1,
NP_001311169.1,
NP_001311167.1,
XP_006723627.1,
NP_001311166.1,
NP_001311165.1,
XP_006723628.1,
NP_001338668.1,
XP_011527536.1,
XP_024307648.1
|
| Others |
UniRef100:
UniRef100_Q9BY32,
UniRef100_A0A2I2ZDH0,
UniRef100_Q8WWI0
UniRef90:
UniRef90_Q8WWI0,
UniRef90_Q9BY32,
UniRef90_A0A2I3T0U9
UniRef50:
UniRef50_Q8WWI0,
UniRef50_G3VP34,
UniRef50_Q9BY32
UniGene:
Hs.415299
CCDS:
CCDS46576.1,
CCDS58762.1,
CCDS13051.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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