| Type | Description |
|---|---|
| Definition | activating transcription factor 7 interacting protein |
| Date | Results | Publications |
|---|---|---|
| 2020-05-23 10:07:00 | ATF7IP promotes the nuclear localization of SETDB1. | 31576654 |
| 2019-05-18 10:07:00 | Although these genes are normally expressed at low amounts in hESCs, HTT knockdown (KD) reduces their induction during neural differentiation. Notably, mutant expanded polyglutamine repeats in HTT diminish its interaction with ATF7IP-SETDB1 complex and trigger H3K9me3 in HD-iPSCs. | 30452683 |
| 2018-01-13 14:20:00 | Here we report on a special case of a Ph-like acute lymphoblastic leukemia patient who had a variant ATF7IP/PDGFRB fusion. In this case, a variant fusion was created between ATF7IP exon 9 (instead of exon 13) and PDGFRB exon 11, resulting in the loss of 411 nucleotides and 137 amino acids in the ATF7IP/PDGFRB fusion cDNA and its encoded chimeric protein, respectively. | 29133777 |
| 2017-11-26 00:01:00 | these data identify a critical functional role for ATF7IP in heterochromatin formation by regulating SETDB1 abundance in the nucleus. | 27732843 |
| 2016-08-06 10:16:00 | results indicate that ATF7IP does not directly modulate SETDB1 catalytic activity, suggesting alternate roles, such as affecting cellular localization or mediating interaction with additional binding partners. | 26813693 |
| Type | IDs |
|---|---|
| Synonymous | AM, ATF-IP, MCAF, MCAF1, p621 |
| Gene |
UniProtKB-ID:
MCAF1_HUMAN,
B3KNI7_HUMAN,
B3KQF8_HUMAN,
A0A024RAY1_HUMAN
UniprotKB:
Q6VMQ6,
B3KNI7,
B3KQF8,
A0A024RAY1
UniParc:
UPI00001FB6B1,
UPI0000E59502,
UPI000015F4E0,
UPI000015D95E,
UPI0000E00418,
UPI0001EE42CD
EMBL:
AK001001,
AK027575,
AJ242978,
AK001550,
AY337596,
CH471094,
AC124892,
AF425650,
AC007782,
AC008114,
AK074868,
AC008814,
BC063855,
BC037312
Ensembl:
ENSG00000171681
KO:
hsa:55729
|
| Nucleutide sequences |
EMBL-CDS:
BAA91751.1,
EAW96320.1,
AAH37312.1,
CAB45135.1,
AAQ92978.1,
AAO91864.1,
AAH63855.1,
BAG51349.1,
BAG52020.1,
EAW96315.1,
EAW96314.1
Gene_ORFName:
hCG_2009476
Ensembl_TRS:
ENST00000536444,
ENST00000543189,
ENST00000540793,
ENST00000261168,
ENST00000544627
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000440440,
ENSP00000443179,
ENSP00000444589,
ENSP00000261168,
ENSP00000445955
RefSeq:
NP_001273444.1,
NP_060649.3,
NP_001273443.1,
NP_001375111.1,
NP_851997.1,
NP_001375109.1,
NP_001375108.1,
NP_001375112.1,
NP_001375110.1,
XP_011519058.1,
NP_001375113.1,
XP_006719172.1
|
| Others |
UniRef100:
UniRef100_B3KNI7,
UniRef100_Q6VMQ6,
UniRef100_B3KQF8
UniRef90:
UniRef90_B3KQF8,
UniRef90_Q6VMQ6
UniRef50:
UniRef50_H0XAP2,
UniRef50_Q6VMQ6
UniGene:
Hs.591151
CCDS:
CCDS66327.1,
CCDS8663.1,
CCDS73449.1,
CCDS66326.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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