| Type | Description |
|---|---|
| Definition | dihydropyrimidine dehydrogenase |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:45:00 | Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients. | 32546132 |
| 2021-02-20 13:33:00 | New DPYD variants causing DPD deficiency in patients treated with fluoropyrimidine. | 32529295 |
| 2020-07-11 11:52:00 | In updated analysis of cohort of patients with gastrointestinal malignancies treated with fluoropyrimidines, the prevalence of heterozygous and homozygous DPYD*9A genotypes were 41% and 10%, respectively. The correlation between DPYD*9A genotype and dihydropyrimidine dehydrogenase deficiency clinical phenotype was not reproduced. Previously reported correlation is likely because of small sample size and selection bias. | 31160238 |
| 2020-05-16 13:07:00 | A significant association was observed between DPYD*9A polymorphism and apecitabine and Oxaliplatin (CAPOX) associated toxicities in colorectal cancer patients. | 31653159 |
| 2019-11-16 13:32:00 | Prospective DPYD genotyping can be successfully implemented in routine clinical practice and can reduce the risk of severe fluoropyrimidine toxicities | 30746637 |
| Type | IDs |
|---|---|
| Synonymous | DHP, DHPDHASE, DPD |
| Gene |
UniProtKB-ID:
DPYD_HUMAN
UniprotKB:
Q12882
UniParc:
UPI000006D155,
UPI00000727C7
EMBL:
AC138135,
CH471097,
AC114878,
AC099787,
BC131777,
AB003063,
AL356457,
BC008379,
AK291217,
BT006740,
U57655,
U09178,
BC108742,
U20938,
AC093576,
BX908805,
AC091608,
BC064027,
X95670,
BC131778
Ensembl:
ENSG00000188641
KO:
hsa:1806
|
| Nucleutide sequences |
EMBL-CDS:
CAA64973.1,
BAA89789.1,
AAB07049.1,
AAI08743.1,
EAW73002.1,
BAF83906.1,
AAI31779.1,
AAH64027.1,
AAH08379.1,
AAB51366.1,
AAP35386.1,
AAA57474.1,
AAI31778.1
Ensembl_TRS:
ENST00000370192,
ENST00000306031
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000359211,
ENSP00000307107
RefSeq:
XP_016855997.1,
XP_016855996.1,
NP_001153773.1,
XP_005270619.2,
XP_016855998.1,
XP_016855999.1,
XP_006710460.1,
NP_000101.2
|
| Others |
UniRef100:
UniRef100_Q12882
UniRef90:
UniRef90_Q12882
UniRef50:
UniRef50_Q12882
UniGene:
Hs.335034
CCDS:
CCDS53346.1,
CCDS30777.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员